STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Cooccurrence
Coexpression
Experiments
Databases
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[Homology]
Score
ML0918Conserved hypothetical protein; Multicopper oxidase with polyphenol oxidase activity. (249 aa)    
Predicted Functional Partners:
ML0919
Possible DNA-binding protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.
  
  
 0.955
ftsZ
Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
     
 0.833
ML0920
Hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.
  
  
 0.757
murG
Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
  
  
 0.716
murC
UDP-N-acetyl-muramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
 
     0.698
ftsW
Putative cell division protein FtsW; Identical to the previously sequenced Mycobacterium leprae cell division protein, FtsW, TR:O69553 (EMBL:AL022602) (534 aa); Fasta score E(): 0, 99.8% identity in 534 aa overlap(EMBL:AL022602). Also highly similar many other FtsW-family proteins involved in cell wall formation e.g. from Mycobacterium tuberculosis FtsW-like protein SW:FTWH_MYCTU (SW:O06223) (524 aa); Fasta score E(): 0, 76.5% identity in 528 aa overlap(SW:O06223) and Escherichia coli FtsW SW:FTSW_ECOLI (SW:P16457) (414 aa); Fasta score E(): 3.6e-31, 37.0% identity in 370 aa overlap(SW [...]
  
  
 0.695
ML0916
Putative FtsQ-family protein; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily.
       0.626
murD
UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
     
 0.571
mraY
phospho-N-acetylmuramoyl- pentapeptidetransferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.
     
 0.555
ML0921
Possible membrane protein; Similar to several proteins of unknown function e.g. Mycobacterium tuberculosis TR:O06230 (EMBL:Z95388) (96 aa); Fasta score E(): 2.8e-32, 88.5% identity in 96 aa overlap and Streptomyces coelicolor TR:Q9S2X3 (EMBL:AL109663) (94 aa); Fasta score E(): 2.9e-12, 40.7% identity in 86 aa overlap. Contains possible membrane spanning hydrophobic domains.
 
  
 0.552
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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