STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1147Possible secreted protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD12_MYCLE (P53432) (147 aa); Fasta score E(): 0, 100.0% identity in 147 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1312 TR:YD12_MYCTU. Contains a possible N-terminal signal sequence. (147 aa)    
Predicted Functional Partners:
atpC
ATP synthase [epsilon] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane.
       0.859
atpG
ATP synthase [gamma] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
       0.769
ML1155
Conserved hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family.
     
 0.755
atpA
ATP synthase [alpha] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.
       0.751
atpD
ATP synthase [beta] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family.
       0.750
atpE
Probable ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
       0.674
ML1584
Possible conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2876 SW:YS76_MYCTU (Q10802) (104 aa); Fasta score E(): 3.3e-26, 75.0% identity in 88 aa overlap. Contains possible membrane spanning hydrophobic domains.
  
     0.666
ML0994
Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49835 (EMBL:U00019) (232 aa); Fasta score E(): 0, 99.6% identity in 232 aa overlap. Also highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv2728c TR:O33233 (EMBL:Z98209) (231 aa); Fasta score E(): 0, 68.5% identity in 232 aa overlap and Streptomyces coelicolor TR:O69964 (EMBL:AL022268) (237 aa); Fasta score E(): 1.3e-13, 32.9% identity in 243 aa overlap.
  
     0.646
lpqB
Putative lipoprotein; Similar to Mycobacterium tuberculosis putative lipoprotein RV3244C OR MTCY20B11.19C TR:O05889 (EMBL:Z95121) fasta scores: E(): 0, 87.9% id in 579 aa, and to Streptomyces coelicolor putative lipoprotein SCE33.13C TR:CAB90922 (EMBL:AL355774) fasta scores: E(): 0.00039, 24.4% id in 624 aa. Contains a probable N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
  
     0.638
ML2295
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis putative alkaline serine protease Rv3668c or MTV025.016C TR:O69636 (EMBL:AL022121) (232 aa) fasta scores: E(): 0, 77.1% id in 231 aa. Shows weak similarity to the C-terminal half of some proteases e.g. Thermomonospora fusca alkaline serine protease precursor TR:O86984 (EMBL:U65895) (368 aa) fasta scores: E(): 0.0018, 31.4% id in 153 aa.
  
     0.635
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: low (28%) [ZH]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.