STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1155Conserved hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (220 aa)    
Predicted Functional Partners:
ML1147
Possible secreted protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD12_MYCLE (P53432) (147 aa); Fasta score E(): 0, 100.0% identity in 147 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1312 TR:YD12_MYCTU. Contains a possible N-terminal signal sequence.
     
 0.755
whiB1
Putative transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.666
ML2073
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 24.0 kda protein Rv1830 SW:YI30_MYCTU (Q50603) fasta scores: E(): 0, 90.0% in 231 aa, and to Streptomyces coelicolor hypothetical 19.1 kda protein TR:CAB88877 (EMBL:AL353861) fasta scores: E(): 3.7e-30, 64.8% in 145 aa.
  
     0.627
dnaN
Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...]
  
 
 
 0.618
ogt
Probable methylated-DNA-protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
     
 0.611
whiB2
Putative transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
  
     0.603
ML0642
Similar to M. tuberculosis Rv3195, conserved hypothetical protein, TR:O53341 (EMBL:AL123456) (472 aa); Fasta score E(): 0, 79.2% identity in 475 aa overlap. Similar to Streptomyces coelicolor SCE9.14C, hypothetical protein, TR:Q9X8I7 (EMBL:AL049841) (375 aa); Fasta score E(): 4.9e-12, 24.9% identity in 305 aa overlap. previously sequenced as TR:Q49746 (EMBL:U00016) (479 aa); Fasta score E(): 0, 99.8% identity in 479 aa overlap.
  
     0.582
ML0986
Conserved hypothetical protein; Highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv2738c TR:O33281 (EMBL:AL008967) (68 aa); Fasta score E(): 7.9e-24, 85.1% identity in 67 aa overlap and Streptomyces coelicolor TR:O50484 (EMBL:AL020958) (64 aa); Fasta score E(): 2.5e-08, 44.4% identity in 63 aa overlap.
      
 0.579
ML0603
Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
  
   
 0.569
dnaE
DNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.
      
 0.553
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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