node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML1171 | ML1173 | gene:17575001 | gene:17575003 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% identity in 256 aa overlap; Belongs to the AtsA family. | 0.621 |
ML1171 | ML1175 | gene:17575001 | gene:17575005 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.448 |
ML1171 | murI | gene:17575001 | gene:17575002 | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.893 |
ML1173 | ML1171 | gene:17575003 | gene:17575001 | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% identity in 256 aa overlap; Belongs to the AtsA family. | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | 0.621 |
ML1173 | ML1175 | gene:17575003 | gene:17575005 | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% identity in 256 aa overlap; Belongs to the AtsA family. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.711 |
ML1173 | murI | gene:17575003 | gene:17575002 | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% identity in 256 aa overlap; Belongs to the AtsA family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.621 |
ML1175 | ML1171 | gene:17575005 | gene:17575001 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Possible conserved integral membrane protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD37_MYCLE (P53426) (251 aa); Fasta score E(): 0, 100.0% identity in 238 aa overlap. Also highly similar to other proteins of undefined function e.g. Mycobacterium tuberculosis hypothetical protein Rv1337 SW:YD37_MYCTU (Q10647) (240 aa); Fasta score E(): 0, 73.2% identity in 231 aa overlap. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01694 Rhomboid, Rhomboid family. | 0.448 |
ML1175 | ML1173 | gene:17575005 | gene:17575003 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein SW:YD39_MYCLE (P50474) (284 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Also highly similar to several other proteins of unknown function e.g. Mycobacterium tuberculosis Rv1339 SW:YD39_MYCTU and Streptomyces coelicolor TR:Q9S2H3 (EMBL:AL096852) (250 aa); Fasta score E(): 0, 43.0% identity in 256 aa overlap; Belongs to the AtsA family. | 0.711 |
ML1175 | murI | gene:17575005 | gene:17575002 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.942 |
alr | murB | gene:17574194 | gene:17576310 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | 0.493 |
alr | murD | gene:17574194 | gene:17574738 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.716 |
alr | murF | gene:17574194 | gene:17574736 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.985 |
alr | murG | gene:17574194 | gene:17574740 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.618 |
alr | murI | gene:17574194 | gene:17575002 | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.873 |
gltB | murI | gene:17573873 | gene:17575002 | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.700 |
gltB | purQ | gene:17573873 | gene:17576076 | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] | 0.900 |
murB | alr | gene:17576310 | gene:17574194 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.493 |
murB | murD | gene:17576310 | gene:17574738 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.938 |
murB | murF | gene:17576310 | gene:17574736 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.946 |
murB | murG | gene:17576310 | gene:17574740 | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.946 |