STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1176Possible conserved membrane protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD42_MYCLE (P54133) (119 aa); Fasta score E(): 0, 100.0% identity in 119 aa overlap. Also highly similar to hypothetical proteins from Mycobacterium tuberculosis Rv1342c TR:YD42_MYCTU and Streptomyces coelicolor TR:Q9X948 (EMBL:AJ237976) (109 aa); Fasta score E(): 7.7e-11, 36.5% identity in 96 aa overlap. Contains possible membrane spanning hydrophobic domains. (119 aa)    
Predicted Functional Partners:
ML1177
Possible lipoprotein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein SW:YD43_MYCLE (P54134) (126 aa); Fasta score E(): 0, 99.2% identity in 126 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv1343c SW:YD43_MYCTU (Q11013) (126 aa); Fasta score E(): 0, 78.4% identity in 125 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
       0.859
ML1706
Conserved hypothetical protein; Highly similar to proteins of undefined function from Streptomyces coelicolor TR:Q9Z586 (EMBL:AL035569) (331 aa); Fasta score E(): 0, 38.6% identity in 337 aa overlap and Mycobacterium tuberculosis RV3015C TR:O53262 (EMBL:AL021287) (337 aa); Fasta score E(): 0, 78.3% identity in 337 aa overlap.
  
   
 0.553
ML0284
Similar to M. tuberculosis Rv0360c, hypothetical protein, TR:O06310 (EMBL:AL123456) (145 aa); Fasta score E(): 0, 85.4% identity in 137 aa overlap and Streptomyces coelicolor SCH10.25C, hypothetical protein, TR:Q9X8R4 (EMBL:AL049754) (143 aa); Fasta score E(): 8.2e-27, 56.2% identity in 130 aa overlap. Previously sequenced as TR:O69598 (EMBL:AL023514) (137 aa); Fasta score E(): 0, 100.0% identity in 137 aa overlap.
  
   
 0.543
ML0876
Putative membrane protein; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
  
   
 0.504
ML1638
Conserved hypothetical protein; Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis RV2229C SW:YM29_MYCTU (Q10513) (245 aa); Fasta score E(): 0, 60.9% identity in 230 aa overlap. Contains a possible coiled-coil between residues 100..139.
  
     0.478
ML0561
Putative membrane protein; Similar to M. tuberculosis Rv1417, hypothetical protein, SW:YE17_MYCTU (P71686) (154 aa); Fasta score E(): 0, 75.5% identity in 143 aa overlap. Similar to other hypothetical proteins e.g. Corynebacterium ammoniagenes ribX, hypothetical protein, TR:O24754 (EMBL:AB003693) (184 aa); Fasta score E(): 2.1e-15, 34.5% identity in 148 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
  
   
 0.469
ML1485
Conserved hypothetical protein; Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis RV2466C TR:O53193 (EMBL:AL02124) (207 aa); Fasta score E(): 0, 80.6% identity in 206 aa overlap and Streptomyces coelicolor TR:CAB71809 (EMBL:AL138662) (216 aa); Fasta score E(): 0, 52.3% identity in 214 aa overlap.
  
 
 0.460
ML0816
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 31.0 kDa protein Rv3207c or MTCY07D11.19 (285 aa) TR:O05859 (EMBL:Z95120) fasta scores: E(): 0, 80.6% id in 284 aa, and to Streptomyces coelicolor putative membrane protein SC2H12.28c (314 aa) TR:CAB94652 (EMBL:AL359215) fasta scores: E(): 1e-13, 30.2% id in 331 aa.
  
   
 0.453
ML1927
Similar to M. tuberculosis hypothetical protein Rv0430 TR:P96276 (EMBL:Z84724) (102 aa); Fasta score E(): 0, 93.1% identity in 102 aa overlap, and to Streptomyces coelicolor hypothetical protein SCD95A.20 TR:CAB93047 (EMBL:AL357432) (84 aa); Fasta score E(): 4.1e-11, 52.8% identity in 72 aa overlap.
  
   
 0.449
ML0986
Conserved hypothetical protein; Highly similar to proteins of undefined function from Mycobacterium tuberculosis Rv2738c TR:O33281 (EMBL:AL008967) (68 aa); Fasta score E(): 7.9e-24, 85.1% identity in 67 aa overlap and Streptomyces coelicolor TR:O50484 (EMBL:AL020958) (64 aa); Fasta score E(): 2.5e-08, 44.4% identity in 63 aa overlap.
  
   
 0.434
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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