STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mmpL10Previously sequenced Mycobacterium leprae membrane protein MMPL10 SW:MMLA_MYCLE (Q49619) (1008 aa); Fasta score E(): 0, 100.0% identity in 983 aa overlap. Also highly similar to many MMPL-family Mycobacterium tuberculosis proteins e.g. Rv1183 SW:MMLA_MYCTU (O50439) (1002 aa); Fasta score E(): 0, 70.4% identity in 978 aa overlap. Contains possible membrane spanning hydrophobic domains; Similar to ML2378 and ML0137. (983 aa)    
Predicted Functional Partners:
papA3
PKS-associated protein, unknown function; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49618 (EMBL:U00010) (471 aa); Fasta score E(): 0, 99.8% identity in 471 aa overlap. Also highly similar to Mycobacterium tuberculosis proteins encoded downstream of several polyketide synthases e.g. Rv1182 TR:O50438 (EMBL:AL010186) (472 aa); Fasta score E(): 0, 75.8% identity in 471 aa overlap.
 
 
 0.969
pks3
Mycocerosic acid synthase (polyketide synthase); Identical to many polyketide synthases involved in the biosynthesis of mycocerosyl lipids e.g. Mycobacterium tuberculosis probable mycocerosic acid synthase Rv2940c TR:P96291 (EMBL:Z83858) (2111 aa); Fasta score E(): 0, 60.8% identity in 2127 aa overlap and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 58.8% identity in 2127 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase [...]
  
 
 0.809
ML1138
Possible integral membrane protein; Identical to the previously sequenced Mycobacterium leprae SW:YD03_MYCLE (P53431) (153 aa); Fasta score E(): 0, 99.3% identity in 153 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1303 SW:YD03_MYCTU (Q10619) (161 aa); Fasta score E(): 0, 69.8% identity in 149 aa overlap. Contains possible membrane spanning hydrophobic domains.
  
     0.562
ML2604
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 26.8 kda protein RV0184 TR:O07428 (EMBL:Z97050) fasta scores: E(): 0, 81.9% id in 249 aa.
  
   
 0.501
ML2463
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 30.2 kda protein Rv0466 TR:O53751 (EMBL:AL021933) fasta scores: E(): 0, 87.1% id in 264 aa.
  
     0.437
ML2489
Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical 31.8 kda protein rv0383c or mtv036.18c TR:O53718 (EMBL:AL021931) fasta scores: E(): 0, 82.2% id in 286 aa. Contains a possible N-terminal signal sequence.
  
     0.436
nrp
Probable peptide synthase; Similar in N-terminus to M. tuberculosis probable peptide synthetase nrp Rv0101 TR:Q10896 (EMBL:Z74410) (2512 aa); Fasta score E(): 0, 65.7% identity in 1089 aa overlap, and to e.g. Streptomyces sp streptothricin peptide synthase TR:O33743 (EMBL:Y10293) (481 aa); Fasta score E(): 5.6e-20, 31.2% identity in 382 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML1051 and ML0243.
 
   0.431
ML1720
Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV3035 TR:O53282 (EMBL:AL021287) (360 aa); Fasta score E(): 0, 75.8% identity in 363 aa overlap.
  
     0.421
ML1234
Highly similar to acyl-CoA synthases from Mycobacterium tuberculosis Rv1185c TR:O50441 (EMBL:AL010186) (578 aa); Fasta score E(): 0, 72.4% identity in 579 aa overlap and Mycobacterium bovis TR:P71495 (EMBL:U7568) (582 aa); Fasta score E(): 0, 63.4% identity in 579 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML0100, ML0132, ML0138, ML0243 and ML2358; Belongs to the ATP-dependent AMP-binding enzyme family.
   
 
 0.416
ML0848
ABC transporter; Similar to Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein Rv2326c or MTCY3G12.08 SW:YN26_MYCTU (P71886) (697 aa) fasta scores: E(): 0, 76.9% id in 697 aa. Shares similar domains with many ABC-type transporters e.g. Streptomyces roseofulvus ATPase component of putative ABC transporter frnD TR:O68910 (EMBL:AF058302) (524 aa) fasta scores: E(): 8.4e-14, 31.5% id in 495 aa and Synechococcus sp. nitrate transport ATP-binding protein NrtD nrtD SW:NRTD_SYNP7 (P38046) (274 aa) fasta scores: E(): 1.6e-12, 34.8% id in 198 aa. Previously sequenced as [...]
  
   
 0.415
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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