node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0151 | aroF | gene:17573966 | gene:17574337 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.962 |
ML0151 | entC | gene:17573966 | gene:17574633 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Similar to Mycobacterium tuberculosis putative isochorismate synthase entC or Rv3215 or MTCY07D11.11c (372 aa) TR:O05851 (EMBL:Z95120) fasta scores: E(): 0, 73.5% id in 366 aa and to Bacillus subtilis isochorismate synthase dhbC (398 aa) SW:DHBC_BACSU (P45744) fasta scores: E(): 0, 37.9% id in 396 aa. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar to ML0236 and ML1269. | 0.875 |
ML0151 | pabA | gene:17573966 | gene:17573826 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | EC_number=4.1.3.-; Similar to M. tuberculosis pabA, p-aminobenzoate synthase glutamine amidotransferase, TR:Q50183 (EMBL:Z70722) (232 aa); Fasta score E(): 0, 100.0% identity in 232 aa overlap (EMBL:AL123456) (232 aa); Fasta score E(): 0, 100.0% identity in 232 aa overlap and to Azospirillum brasilense trpG, anthranilate synthase component II, SW:TRPG_AZOBR (P26922) (196 aa); Fasta score E(): 0, 56.1% identity in 187 aa overlap. Previously sequenced as TR:Q50183. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferase [...] | 0.894 |
ML0151 | pabB | gene:17573966 | gene:17574053 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | EC_number=4.1.3.-; Similar to M. tuberculosis pabB, Rv1005c, putative para-aminobenzoate synthase component I, TR:O05591 (EMBL:Z94752) (458 aa); Fasta score E(): 0, 79.1% identity in 412 aa overlap. Similar to many e.g. Escherichia coli para-aminobenzoate synthase component I, SW:PABB_ECOLI (P05041) (453 aa); Fasta score E(): 5.5e-31, 35.2% identity in 378 aa overlap. When compared to the predicted M. tuberculosis translation, this CDS is missing the N-terminal 30 aa, thus it may be a pseudogene. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar t [...] | 0.818 |
ML0151 | trpE | gene:17573966 | gene:17575101 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.936 |
ML1270 | trpA | gene:17575102 | gene:17575105 | Possible conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV1610 TR:O06128 (EMBL:Z95554) (235 aa); Fasta score E(): 0, 65.8% identity in 231 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases. | Tryptophan synthase [alpha] chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.765 |
ML1270 | trpB | gene:17575102 | gene:17575104 | Possible conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV1610 TR:O06128 (EMBL:Z95554) (235 aa); Fasta score E(): 0, 65.8% identity in 231 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases. | Tryptophan synthase [beta] chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.765 |
ML1270 | trpC | gene:17575102 | gene:17575103 | Possible conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV1610 TR:O06128 (EMBL:Z95554) (235 aa); Fasta score E(): 0, 65.8% identity in 231 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases. | Highly similar to many indole-3-glycerol phosphate synthases (EC 4.1.1.48) involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1611 SW:TRPC_MYCTU (O06129) (272 aa); Fasta score E(): 0, 90.8% identity in 272 aa overlap and Streptomyces coelicolor SW:TRC1_STRCO (O68814) (269 aa); Fasta score E(): 0, 64.1% identity in 262 aa overlap. Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases. Contains PS00614 Indole-3-glycerol phosphate synthase signature. | 0.859 |
ML1270 | trpE | gene:17575102 | gene:17575101 | Possible conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV1610 TR:O06128 (EMBL:Z95554) (235 aa); Fasta score E(): 0, 65.8% identity in 231 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.859 |
aroF | ML0151 | gene:17574337 | gene:17573966 | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | 0.962 |
aroF | entC | gene:17574337 | gene:17574633 | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Similar to Mycobacterium tuberculosis putative isochorismate synthase entC or Rv3215 or MTCY07D11.11c (372 aa) TR:O05851 (EMBL:Z95120) fasta scores: E(): 0, 73.5% id in 366 aa and to Bacillus subtilis isochorismate synthase dhbC (398 aa) SW:DHBC_BACSU (P45744) fasta scores: E(): 0, 37.9% id in 396 aa. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar to ML0236 and ML1269. | 0.895 |
aroF | pabA | gene:17574337 | gene:17573826 | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | EC_number=4.1.3.-; Similar to M. tuberculosis pabA, p-aminobenzoate synthase glutamine amidotransferase, TR:Q50183 (EMBL:Z70722) (232 aa); Fasta score E(): 0, 100.0% identity in 232 aa overlap (EMBL:AL123456) (232 aa); Fasta score E(): 0, 100.0% identity in 232 aa overlap and to Azospirillum brasilense trpG, anthranilate synthase component II, SW:TRPG_AZOBR (P26922) (196 aa); Fasta score E(): 0, 56.1% identity in 187 aa overlap. Previously sequenced as TR:Q50183. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferase [...] | 0.876 |
aroF | pabB | gene:17574337 | gene:17574053 | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | EC_number=4.1.3.-; Similar to M. tuberculosis pabB, Rv1005c, putative para-aminobenzoate synthase component I, TR:O05591 (EMBL:Z94752) (458 aa); Fasta score E(): 0, 79.1% identity in 412 aa overlap. Similar to many e.g. Escherichia coli para-aminobenzoate synthase component I, SW:PABB_ECOLI (P05041) (453 aa); Fasta score E(): 5.5e-31, 35.2% identity in 378 aa overlap. When compared to the predicted M. tuberculosis translation, this CDS is missing the N-terminal 30 aa, thus it may be a pseudogene. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar t [...] | 0.882 |
aroF | trpA | gene:17574337 | gene:17575105 | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase [alpha] chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.759 |
aroF | trpB | gene:17574337 | gene:17575104 | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Tryptophan synthase [beta] chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.678 |
aroF | trpC | gene:17574337 | gene:17575103 | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Highly similar to many indole-3-glycerol phosphate synthases (EC 4.1.1.48) involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1611 SW:TRPC_MYCTU (O06129) (272 aa); Fasta score E(): 0, 90.8% identity in 272 aa overlap and Streptomyces coelicolor SW:TRC1_STRCO (O68814) (269 aa); Fasta score E(): 0, 64.1% identity in 262 aa overlap. Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases. Contains PS00614 Indole-3-glycerol phosphate synthase signature. | 0.589 |
aroF | trpD | gene:17574337 | gene:17574709 | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Putative anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.669 |
aroF | trpE | gene:17574337 | gene:17575101 | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.970 |
entC | ML0151 | gene:17574633 | gene:17573966 | Similar to Mycobacterium tuberculosis putative isochorismate synthase entC or Rv3215 or MTCY07D11.11c (372 aa) TR:O05851 (EMBL:Z95120) fasta scores: E(): 0, 73.5% id in 366 aa and to Bacillus subtilis isochorismate synthase dhbC (398 aa) SW:DHBC_BACSU (P45744) fasta scores: E(): 0, 37.9% id in 396 aa. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar to ML0236 and ML1269. | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | 0.875 |
entC | aroF | gene:17574633 | gene:17574337 | Similar to Mycobacterium tuberculosis putative isochorismate synthase entC or Rv3215 or MTCY07D11.11c (372 aa) TR:O05851 (EMBL:Z95120) fasta scores: E(): 0, 73.5% id in 366 aa and to Bacillus subtilis isochorismate synthase dhbC (398 aa) SW:DHBC_BACSU (P45744) fasta scores: E(): 0, 37.9% id in 396 aa. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar to ML0236 and ML1269. | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.895 |