Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2135C TR:O06240 (EMBL:Z95388) (236 aa); Fasta score E(): 0, 75.2% identity in 250 aa overlap. Also similar, in regions, to several putative phosphoglycerate mutases e.g. Escherichia coli SW:PMG2_ECOLI (P36942) (215 aa); Fasta score E(): 1.2e-06, 27.1% identity in 192 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family.

Similar to Mycobacterium tuberculosis hypothetical protein RV2137C TR:O06238 (EMBL:Z95388) (137 aa); Fasta score E(): 1.3e-28, 75.5% identity in 106 aa overlap.

Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2134C TR:O06241 (EMBL:Z95388) (195 aa); Fasta score E(): 0, 91.1% identity in 192 aa overlap.

Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2133C TR:O06242 (EMBL:Z95388) (262 aa); Fasta score E(): 0, 79.4% identity in 262 aa overlap.

Putative undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) in the cis configuration with (2Z,6E)-farnesyl diphosphate (Z-FPP or EZ-FPP) generating the 50 carbon product trans,polycis-decaprenyl diphosphate. When (2E,6E)-farnesyl diphosphate (E-FPP or EE-FPP) is used in vitro, both primary products decaprenyl diphosphate and (2E,6E,10E)-geranylgeranyl diphosphate (EEE-GGPP) are synthesized. M.tuberculosis does not synthesize (2E,6E,10Z)- geranylgeranyl diphosphate (EEZ-GGPP) and heptaprenyl diphosphate. Can also accept many dif [...]

Possible inositol monophosphatase family protein; Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'- phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I-1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F-6-P)) and AMP in vitro, but this might [...]

cysteinyl-tRNA synthase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.

Possible undecaprenyl pyrophosphate synthetase; Generates Z-farnesyl diphosphate (Z-FPP) from isopentenyl pyrophosphate (IPP). Z-FPP is the precursor of decaprenyl diphosphate, which has a central role in the biosynthesis of the mycobacterial cell wall (By similarity); Belongs to the UPP synthase family. Z-FPP synthase subfamily.

Penicillin-binding protein 2; Identical to the previously sequenced Mycobacterium leprae penicillin binding protein 2 TR:O69558 (EMBL:AL022602) (675 aa); Fasta score E(): 0, 99.9% identity in 675 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O06214 (EMBL:Z95388) (679 aa); Fasta score E(): 0, 80.6% identity in 677 aa overlap(EMBL:Z95388) and to many other penicillin-binding proteins e.g. Neisseria meningitidis SW:PBP2_NEIME (P11882) (581 aa); Fasta score E(): 4.3e-29, 32.4% identity in 590 aa overlap(P11882). Contains Pfam match to [...]