STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (320 aa)    
Predicted Functional Partners:
argG
Arginosuccinate synthase; Highly similar to many argininosuccinate synthases (EC 6.3.4.5) involved in arginine biosynthesis, including: Streptomyces clavuligerus SW:ASSY_STRCL (P50986) (397 aa); Fasta score E(): 0, 67.0% identity in 397 aa overlap and Mycobacterium tuberculosis SW:ASSY_MYCTU (P94993) (398 aa); Fasta score E(): 0, 91.0% identity in 398 aa overlap. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase. Contains PS00564 Argininosuccinate synthase signature 1. Contains PS00565 Argininosuccinate synthase signature 2.
  
 
 0.999
argJ
Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
 
 
 0.998
argD
Highly similar to many acetylornithine aminotransferases (EC 2.6.1.11) involved in arginine biosynthesis, including: Escherichia coli SW:ARGD_ECOLI (P18335) (405 aa); Fasta score E(): 0, 38.7% identity in 390 aa overlap and Mycobacterium tuberculosis RV1655 SW:ARGD_MYCTU (P94990) (400 aa); Fasta score E(): 0, 82.9% identity in 397 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site.
  
 0.996
argR
Arginine repressor; Regulates arginine biosynthesis genes.
  
  
 0.996
carB
Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1.
 
 
 0.995
argB
Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 
  
 0.992
argC
N-acetyl-[gamma]-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.
 
  
 0.984
argH
Arginosuccinate lyase; Highly similar to many argininosuccinate lyases (EC 4.3.2.1) involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa); BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa); Fasta score E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature.
 
  
 0.970
carA
Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...]
 
 
 0.965
pyrB
Similar to M. tuberculosis pyrB, Rv1380, aspartate carbamoyltransferase, SW:PYRB_MYCTU (P71808) (319 aa); Fasta score E(): 0, 89.9% identity in 318 aa overlap. Similar to many e.g. Pseudomonas putida, aspartate carbamoyltransferase, SW:PYRB_PSEPU (Q59711) (334 aa); Fasta score E(): 0, 47.3% identity in 317 aa overlap. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature; Shows weak similarity to ML1410; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCas [...]
 
  
0.847
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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