STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ML1454Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (214 aa)    
Predicted Functional Partners:
ML1463
Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
 
 0.994
cinA
Similar to M. tuberculosis competence damage protein homolog cinA Rv1901 TR:O07731 (EMBL:Z97193) (430 aa); Fasta score E(): 0, 77.0% identity in 431 aa overlap, and to e.g. Streptococcus pneumoniae putative competence-damage protein SW:CINA_STRPN (P54184) (418 aa); Fasta score E(): 1.4e-22, 31.0% identity in 439 aa overlap; Belongs to the CinA family.
  
 
 0.958
nadC
Nicotinate-nucleotide pyrophosphatase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
    
 0.955
ML1453
Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
 
  
 0.953
ML1359
Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
 
 0.934
ML1511
Conserved hypothetical protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily.
   
 0.928
pntAB
Pyridine transhydrogenase subunit [alpha]2; Similar to Mycobacterium tuberculosis PntAB OR RV0156 TR:P96833 (EMBL:Z92770) fasta scores: E(): 3.5e-30, 83.0% id in 100 aa, and to Rhodospirillum rubrum nicotinamide nucleotide transhydrogenase, subunit alpha 2 PntAB TR:Q59764 (EMBL:U01158) fasta scores: E(): 6.1e-11, 42.7% id in 89 aa. Note this is the equivalent to the very C-terminal hydrophobic domain of the larger E. coli and bovine mitochondrial enzymes. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyrid [...]
     
 0.901
pntAA
Pyridine transhydrogenase subunit [alpha]1; Similar to Mycobacterium tuberculosis PntAA OR RV0155 TR:P96832 (EMBL:Z92770) fasta scores: E(): 0, 87.9% id in 365 aa, Haemophilus influenzae NAD PntA SW:PNTA_HAEIN (P43842) fasta scores: E(): 0, 42.6% id in 364 aa, and to Escherichia coli NAD PntA SW:PNTA_ECOLI (P07001; P76888) fasta scores: E(): 0, 42.1% id in 363 aa. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase.
     
 0.901
pntB
Pyridine transhydrogenase subunit [beta]; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.900
ML1452
Possible phosphoglycerate mutase; Similar to several including: Salmonella typhimurium SW:COBC_SALTY (P39701) (234 aa); Fasta score E(): 5.4e-09, 29.4% identity in 197 aa overlap alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.-) involved in cobalamin biosynthesis. Also highly simlar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2419c TR:P71724 (EMBL:Z81368) (223 aa); Fasta score E(): 0, 80.4% identity in 224 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Contains PS00175 Phosphoglycerate mutase family phosphohisti [...]
  
    0.873
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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