node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML1359 | ML1454 | gene:17575197 | gene:17575292 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.934 |
ML1359 | ML1463 | gene:17575197 | gene:17575301 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.944 |
ML1359 | ML1511 | gene:17575197 | gene:17575352 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Conserved hypothetical protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. | 0.911 |
ML1359 | pntAA | gene:17575197 | gene:17576502 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Pyridine transhydrogenase subunit [alpha]1; Similar to Mycobacterium tuberculosis PntAA OR RV0155 TR:P96832 (EMBL:Z92770) fasta scores: E(): 0, 87.9% id in 365 aa, Haemophilus influenzae NAD PntA SW:PNTA_HAEIN (P43842) fasta scores: E(): 0, 42.6% id in 364 aa, and to Escherichia coli NAD PntA SW:PNTA_ECOLI (P07001; P76888) fasta scores: E(): 0, 42.1% id in 363 aa. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. | 0.905 |
ML1359 | pntAB | gene:17575197 | gene:17576501 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Pyridine transhydrogenase subunit [alpha]2; Similar to Mycobacterium tuberculosis PntAB OR RV0156 TR:P96833 (EMBL:Z92770) fasta scores: E(): 3.5e-30, 83.0% id in 100 aa, and to Rhodospirillum rubrum nicotinamide nucleotide transhydrogenase, subunit alpha 2 PntAB TR:Q59764 (EMBL:U01158) fasta scores: E(): 6.1e-11, 42.7% id in 89 aa. Note this is the equivalent to the very C-terminal hydrophobic domain of the larger E. coli and bovine mitochondrial enzymes. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyrid [...] | 0.907 |
ML1359 | pntB | gene:17575197 | gene:17576500 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Pyridine transhydrogenase subunit [beta]; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.903 |
ML1452 | ML1453 | gene:17575290 | gene:17575291 | Possible phosphoglycerate mutase; Similar to several including: Salmonella typhimurium SW:COBC_SALTY (P39701) (234 aa); Fasta score E(): 5.4e-09, 29.4% identity in 197 aa overlap alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.-) involved in cobalamin biosynthesis. Also highly simlar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2419c TR:P71724 (EMBL:Z81368) (223 aa); Fasta score E(): 0, 80.4% identity in 224 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Contains PS00175 Phosphoglycerate mutase family phosphohisti [...] | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.870 |
ML1452 | ML1454 | gene:17575290 | gene:17575292 | Possible phosphoglycerate mutase; Similar to several including: Salmonella typhimurium SW:COBC_SALTY (P39701) (234 aa); Fasta score E(): 5.4e-09, 29.4% identity in 197 aa overlap alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.-) involved in cobalamin biosynthesis. Also highly simlar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2419c TR:P71724 (EMBL:Z81368) (223 aa); Fasta score E(): 0, 80.4% identity in 224 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Contains PS00175 Phosphoglycerate mutase family phosphohisti [...] | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.873 |
ML1453 | ML1452 | gene:17575291 | gene:17575290 | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | Possible phosphoglycerate mutase; Similar to several including: Salmonella typhimurium SW:COBC_SALTY (P39701) (234 aa); Fasta score E(): 5.4e-09, 29.4% identity in 197 aa overlap alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.-) involved in cobalamin biosynthesis. Also highly simlar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2419c TR:P71724 (EMBL:Z81368) (223 aa); Fasta score E(): 0, 80.4% identity in 224 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Contains PS00175 Phosphoglycerate mutase family phosphohisti [...] | 0.870 |
ML1453 | ML1454 | gene:17575291 | gene:17575292 | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.953 |
ML1454 | ML1359 | gene:17575292 | gene:17575197 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.934 |
ML1454 | ML1452 | gene:17575292 | gene:17575290 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Possible phosphoglycerate mutase; Similar to several including: Salmonella typhimurium SW:COBC_SALTY (P39701) (234 aa); Fasta score E(): 5.4e-09, 29.4% identity in 197 aa overlap alpha-ribazole-5'-phosphate phosphatase (EC 3.1.3.-) involved in cobalamin biosynthesis. Also highly simlar to several proteins of undefined function e.g. Mycobacterium tuberculosis Rv2419c TR:P71724 (EMBL:Z81368) (223 aa); Fasta score E(): 0, 80.4% identity in 224 aa overlap. Contains Pfam match to entry PF00300 PGAM, Phosphoglycerate mutase family. Contains PS00175 Phosphoglycerate mutase family phosphohisti [...] | 0.873 |
ML1454 | ML1453 | gene:17575292 | gene:17575291 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.953 |
ML1454 | ML1463 | gene:17575292 | gene:17575301 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.994 |
ML1454 | ML1511 | gene:17575292 | gene:17575352 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Conserved hypothetical protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form; Belongs to the sirtuin family. Class III subfamily. | 0.928 |
ML1454 | cinA | gene:17575292 | gene:17575867 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Similar to M. tuberculosis competence damage protein homolog cinA Rv1901 TR:O07731 (EMBL:Z97193) (430 aa); Fasta score E(): 0, 77.0% identity in 431 aa overlap, and to e.g. Streptococcus pneumoniae putative competence-damage protein SW:CINA_STRPN (P54184) (418 aa); Fasta score E(): 1.4e-22, 31.0% identity in 439 aa overlap; Belongs to the CinA family. | 0.958 |
ML1454 | nadC | gene:17575292 | gene:17575058 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Nicotinate-nucleotide pyrophosphatase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. | 0.955 |
ML1454 | pntAA | gene:17575292 | gene:17576502 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Pyridine transhydrogenase subunit [alpha]1; Similar to Mycobacterium tuberculosis PntAA OR RV0155 TR:P96832 (EMBL:Z92770) fasta scores: E(): 0, 87.9% id in 365 aa, Haemophilus influenzae NAD PntA SW:PNTA_HAEIN (P43842) fasta scores: E(): 0, 42.6% id in 364 aa, and to Escherichia coli NAD PntA SW:PNTA_ECOLI (P07001; P76888) fasta scores: E(): 0, 42.1% id in 363 aa. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. | 0.901 |
ML1454 | pntAB | gene:17575292 | gene:17576501 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Pyridine transhydrogenase subunit [alpha]2; Similar to Mycobacterium tuberculosis PntAB OR RV0156 TR:P96833 (EMBL:Z92770) fasta scores: E(): 3.5e-30, 83.0% id in 100 aa, and to Rhodospirillum rubrum nicotinamide nucleotide transhydrogenase, subunit alpha 2 PntAB TR:Q59764 (EMBL:U01158) fasta scores: E(): 6.1e-11, 42.7% id in 89 aa. Note this is the equivalent to the very C-terminal hydrophobic domain of the larger E. coli and bovine mitochondrial enzymes. Contains possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyrid [...] | 0.901 |
ML1454 | pntB | gene:17575292 | gene:17576500 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Pyridine transhydrogenase subunit [beta]; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.900 |