STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
truBtRNA pseudouridine 55 synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (320 aa)    
Predicted Functional Partners:
ML1555
Probable ribosome-binding factor; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.
  
  
 0.980
ribF
Putative riboflavin kinase; Similar to Mycobacterium tuberculosis riboflavin kinase ribF or Rv2786c or MTV002.51C TR:O33328 (EMBL:AL008967) (331 aa) fasta scores: E(): 0, 87.5% id in 327 aa and to many others e.g. Corynebacterium ammoniagenes riboflavin biosynthesis protein RibF (includes riboflavin kinase) ribF SW:RIBF_CORAM (Q59263) (338 aa) fasta scores: E(): 0, 47.7% id in 321 aa. Previously sequenced as TR:O32968 (EMBL:Z98741). Contains Pfam match to entry PF01687 FAD_Synth, Riboflavin kinase / FAD synthetase.
 
  
 0.952
infB
Initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
 
 0.947
guaA
Putative GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
  
 0.915
ML1547
Conserved hypothetical protein; Similar to a number of proteins essential for the production of iron chelators e.g. Escherichia coli enterobactin synthetase component D SW:ENTD_ECOLI (P19925) (209 aa); Fasta score E(): 0.002, 29.4% identity in 177 aa overlap. Also similar to Streptomyces sp. L-proline 3-hydroxylase TR:O24813 (EMBL:AB007189) (208 aa); Fasta score E(): 0, 50.7% identity in 209 aa overlap and a hypothetical protein from Mycobacterium tuberculosis RV2794C TR:O33336 (EMBL:AL008967) (227 aa); Fasta score E(): 0, 79.7% identity in 227 aa overlap; Belongs to the P-Pant transfe [...]
  
    0.865
ML1548
Conserved hypothetical protein; Highly similar to several proteins of unknown function including: Streptomyces coelicolor TR:O88028 (EMBL:AL031107) (295 aa); Fasta score E(): 0, 54.4% identity in 285 aa overlap and Mycobacterium tuberculosis TR:O33337 (EMBL:AL00896) (324 aa); Fasta score E(): 0, 87.4% identity in 318 aa overlap.
       0.859
rpsO
30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.
  
 
 0.822
truA
Probable pseudouridylate synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
  
 
 0.790
nusA
Probable transcription termination/antitermination factor; Participates in both transcription termination and antitermination.
  
    0.740
rpsA
30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity).
  
 
 0.732
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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