STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acpMAcyl carrier protein (meromycolate extension); Acyl carrier protein involved in meromycolate extension. (115 aa)    
Predicted Functional Partners:
embB
Putative arabinosyl transferase; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family.
   
   0.999
embA
Putative arabinosyl transferase; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family.
   
   0.999
embC
Putative arabinosyl transferase; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family.
   
   0.999
fas
Fatty acid synthase; Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa); Fasta score E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa); Fasta score E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa); Fasta score E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 [...]
  
 0.999
kasA
3-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
 
 0.994
fabD
Malonyl CoA-[ACP] transacylase; Similar to many malonyl CoA-acyl carrier protein transacylases (EC 2.3.1.39) involved in fatty acid biosynthesis, including: Salmonella typhimurium SW:FABD_SALTY (O85140) (308 aa); Fasta score E(): 1.6e-19, 32.7% identity in 303 aa overlap and Mycobacterium tuberculosis SW:FABD_MYCTU (Q10501) (302 aa); Fasta score E(): 0, 82.2% identity in 304 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain.
 
 0.991
kasB
3-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
 
 0.989
ML1657
Acetyl/propionyl CoA carboxylase [beta] subunit; Highly similar to many propionyl-CoA carboxylases involved in fatty acid catabolism including: Rhodococcus erythropolis SW:PCCB_RHOER (Q06101) (476 aa); Fasta score E(): 0, 70.9% identity in 477 aa overlap and Mycobacterium tuberculosis RV2247 SW:PCCB_MYCTU (Q10506) (473 aa); Fasta score E(): 0, 92.8% identity in 473 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML0731.
  
  
 0.903
acpS
Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family.
  
 
 0.788
nrp
Probable peptide synthase; Similar in N-terminus to M. tuberculosis probable peptide synthetase nrp Rv0101 TR:Q10896 (EMBL:Z74410) (2512 aa); Fasta score E(): 0, 65.7% identity in 1089 aa overlap, and to e.g. Streptomyces sp streptothricin peptide synthase TR:O33743 (EMBL:Y10293) (481 aa); Fasta score E(): 5.6e-20, 31.2% identity in 382 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML1051 and ML0243.
  
 
 0.706
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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