STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
coaDProbable phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (157 aa)    
Predicted Functional Partners:
ML1383
Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; In the C-terminal section; belongs to the UPF0157 (GrpB) family.
    
 0.991
dfp
Putative flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
 
  
 0.983
coaA
Pantothenate kinase; Similar to M. tuberculosis pantothenate kinase coaA Rv1092c SW:COAA_MYCTU (O53440) (312 aa); Fasta score E(): 0, 93.6% identity in 312 aa overlap, and to many others e.g. Escherichia coli pantothenate kinase SW:COAA_ECOLI (P15044) (316 aa); Fasta score E(): 0, 53.1% identity in 311 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
     
 0.956
ML0232
Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.
 
  
 0.941
ML1664
Conserved hypothetical protein; Similar to several proteins of undefined function including: Neisseria meningitidis possible DNA methylase TR:CAB83466 (EMBL:AL162752) (189 aa); Fasta score E(): 3.6e-07, 39.6% identity in 96 aa overlap and Mycobacterium tuberculosis Rv2966c TR:P95128 (EMBL:Z83018) (188 aa); Fasta score E(): 0, 72.9% identity in 155 aa overlap. Contains PS00092 N-6 Adenine-specific DNA methylases signature.
 
  
 0.930
guaA
Putative GMP synthase; Catalyzes the synthesis of GMP from XMP.
 
   
 0.629
ribF
Putative riboflavin kinase; Similar to Mycobacterium tuberculosis riboflavin kinase ribF or Rv2786c or MTV002.51C TR:O33328 (EMBL:AL008967) (331 aa) fasta scores: E(): 0, 87.5% id in 327 aa and to many others e.g. Corynebacterium ammoniagenes riboflavin biosynthesis protein RibF (includes riboflavin kinase) ribF SW:RIBF_CORAM (Q59263) (338 aa) fasta scores: E(): 0, 47.7% id in 321 aa. Previously sequenced as TR:O32968 (EMBL:Z98741). Contains Pfam match to entry PF01687 FAD_Synth, Riboflavin kinase / FAD synthetase.
 
   
 0.548
pheT
phenylalanyl-tRNA synthase [beta] subunit; Highly similar to many phenylalanyl-tRNA synthetase beta chains including: Escherichia coli SW:SYFB_ECOLI (P07395) (795 aa); Fasta score E(): 0, 31.0% identity in 851 aa overlap and Mycobacterium tuberculosis RV1649 SW:SYFB_MYCTU (P94985) (831 aa); Fasta score E(): 0, 79.6% identity in 834 aa overlap.
  
   
 0.534
alr
Putative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
 
   
 0.502
metK
Putative S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
   
 0.468
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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