STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (294 aa)    
Predicted Functional Partners:
proB
Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
 
 
 0.902
proA
[gamma]-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 
 0.890
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
     
 0.820
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
     
 0.773
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
     
 0.739
purB
Adenylosuccinate lyase; Similar to Mycobacterium tuberculosis hypothetical 51.0 kda protein cy369.21b RV0777 OR MTCY369.21B TR:P71832 (EMBL:Z80226) fasta scores: E(): 0, 86.4% id in 472 aa, and to Saccharomyces cerevisiae adenylosuccinate lyase ADE13 OR YLR359W OR L8039.12 SW:PUR8_YEAST (Q05911) fasta scores: E(): 0, 34.5% id in 449 aa. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00163 Fumarate lyases signature.
     
 0.724
metE
5-methyltetrahydropteroyltriglutamate- homocysteinmethyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation.; Belongs to the vitamin-B12 independent methionine synthase family.
      
 0.703
ML2429
Possible DNA-binding protein; Weakly similar to several including: Streptomyces coelicolor hypothetical protein TR:Q9WX06 (EMBL:AL079345) (70 aa) fasta scores: E(): 3.4e-14, 68.3% id in 63 aa. Contains a probable helix-turn-helix motif at aa 33-54 (Score 1515, SD +4.35) Contains PS00017 ATP/GTP-binding site motif A (P-loop).
       0.699
gltB
Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature.
     
 0.637
gpdA
Highly similar to many glycerol-3-phosphate dehydrogenases (EC 1.1.1.8) including: Escherichia coli SW:GPDA_ECOLI (P37606) (339 aa); Fasta score E(): 0, 39.9% identity in 341 aa overlap and Mycobacterium tuberculosis RV2982C TR:P95113 (EMBL:Z83018) (334 aa); Fasta score E(): 0, 77.9% identity in 349 aa overlap. Contains Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase.
   
 
 0.587
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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