STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML2434Conserved hypothetical protein; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. (339 aa)    
Predicted Functional Partners:
ML0258
Hypothetical protein; Similar to M. tuberculosis Rv1026, hypothetical protein, TR:P96374 (EMBL:AL123456) (319 aa); Fasta score E(): 0, 77.6% identity in 321 aa overlap. Similar to many bacterial hypothetical proteins and shows weak similarity to N-terminal half of Escherichia coli ppx, exopolyphosphatase, SW:PPX_ECOLI (P29014) (512 aa); Fasta score E(): 6.8e-07, 25.3% identity in 297 aa overlap; Shows weak similarity to ML2434.
  
  
 0.980
relA
Putative GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity).
  
 
 0.909
ML2433
Conserved membrane protein; Similar to Mycobacterium tuberculosis hypothetical 33.1 kda protein Rv0497 SW:Y497_MYCTU (Q11162) (310 aa) fasta scores: E(): 4.6e-21, 54.2% id in 356 aa. Contains multiple possible membrane spanning hydrophobic domains.
       0.859
ML1681
Possible polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family.
 
  
 0.823
ML2432
Similar to Mycobacterium tuberculosis hypothetical protein Rv0498 SW:Y498_MYCTU (Q11163) (280 aa) fasta scores: E(): 0, 89.3% id in 280 aa, and to Streptomyces coelicolor hypothetical protein TR:Q9X8H0 (EMBL:AL049819) (285 aa) fasta scores: E(): 3.2e-30, 51.6% id in 273 aa.
       0.812
ML2435
Similar to Mycobacterium tuberculosis hypothetical protein Rv0495c SW:Y495_MYCTU (Q11160) (296 aa) fasta scores: E(): 0, 82.7% id in 271 aa, and to Streptomyces coelicolor hypothetical protein TR:Q9X8H2 (EMBL:AL049819) (271 aa) fasta scores: E(): 0, 48.4% id in 250 aa.
       0.600
ML0475
Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function.
     
 0.582
ML2429
Possible DNA-binding protein; Weakly similar to several including: Streptomyces coelicolor hypothetical protein TR:Q9WX06 (EMBL:AL079345) (70 aa) fasta scores: E(): 3.4e-14, 68.3% id in 63 aa. Contains a probable helix-turn-helix motif at aa 33-54 (Score 1515, SD +4.35) Contains PS00017 ATP/GTP-binding site motif A (P-loop).
       0.493
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
       0.493
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.