STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (226 aa)    
Predicted Functional Partners:
tkt
Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
  
 0.929
tal
Putative transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
    
 0.909
fba
Putative fructose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.
     
 0.908
ML2452
Hypothetical protein; Weakly similar in parts to Mycobacterium tuberculosis hypothetical protein Rv0477 SW:Y477_MYCTU (Q11144) fasta scores: E(): 1.8e-23, 57.3% id in 110 aa; To M.tuberculosis Rv0477.
  
    0.860
tpi
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
 0.856
pgi
Glucose-6-phosphate isomerase; Similar to M. tuberculosis Rv0946c, pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCTU (P77895) (553 aa); Fasta score E(): 0, 85.5% identity in 552 aa overlap and Mycobacterium smegmatis pgi, glucose-6-phosphate isomerase, SW:G6PI_MYCSM (P96803) (442 aa); Fasta score E(): 0, 84.1% identity in 440 aa overlap. Contains Pfam match to entry PF00342 PGI, Phosphoglucose isomerase. Contains PS00765 Phosphoglucose isomerase signature 1. Contains PS00174 Phosphoglucose isomerase signature 2.
  
 
 0.826
gap
Glyceraldehyde 3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
    
 0.820
eno
Putative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
    
 0.808
ppdK
Pyruvate, phosphate dikinase; Identical to the previously sequenced Mycobacterium leprae pyruvate, phosphate dikinase TR:O05566 (EMBL:Z94723) (601 aa); Fasta score E(): 0, 99.8% identity in 601 aa overlap. Also highly similar to pyruvate, phosphate dikinases from Mycobacterium tuberculosis TR:O06579 (EMBL:Z95585) (490 aa); Fasta score E(): 0, 71.8% identity in 478 aa overlap and Clostridium symbiosumSW:PODK_CLOSY (P22983) (873 aa); Fasta score E(): 0, 35.2% identity in 537 aa overlap. Contains Pfam match to entry PF00391 PEP-utilizers, PEP-utilizing enzymes. Contains Pfam match to entr [...]
    
  0.807
aceE
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.805
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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