STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML2617Similar to Mycobacterium tuberculosis putative membrane protein Mmpl11 RV0202C SW:MMLB_MYCTU (O53653) fasta scores: E(): 0, 72.8% id in 1017 aa, and to Streptomyces coelicolor putative integral membrane protein SC3A4.16C TR:CAB89762 (EMBL:AL354616) fasta scores: E(): 0, 31.8% id in 761 aa. Contains a possible N-terminal signal sequence and multiple other possible membrane spanning hydrophobic domains; Similar to ML2620. (1013 aa)    
Predicted Functional Partners:
ML2616
Similar to Mycobacterium tuberculosis hypothetical protein RV0201C TR:O53652 (EMBL:AL021928) fasta scores: E(): 0, 63.9% id in 158 aa. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign.
     
 0.888
mmpL7
Putative membrane protein; Similar to members of the M. tuberculosis mmpL family of membrane proteins e.g. Rv2942, mmpL7, putative membrane protein, SW:MML7_MYCTU (P96289) (920 aa); Fasta score E(): 0, 68.6% identity in 881 aa overlap. Contains hydrophobic, possible membrane-spanning regions; Similar to ML1231 and ML2378. Similar to pseudogene ML2375.
  
   
 0.765
mrsA
Putative phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
      
 0.753
ML0542
Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
      
 0.747
aac
Highly similar to several mycobacterial aminoglycoside-resistance determinants e.g. Mycobacterium tuberculosis aminoglycoside 2'-n-acetyltransferase Aac OR RV0262C SW:AAC2_MYCTU (P95219; P72033) fasta scores: E(): 0, 78.7% id in 178 aa.
  
     0.731
pknG
Similar to M. tuberculosis pknG, Rv0410c, putative serine/threonine protein kinase, TR:P96256 (EMBL:AL123456) (750 aa); Fasta score E(): 0, 83.1% identity in 756 aa overlap. Similar to many bacterial putative serine/threonine protein kinases e.g. Streptomyces coelicolor SC6D10.09, possible protein kinase, TR:CAB71204 (EMBL:AL138538) (903 aa); Fasta score E(): 0, 42.0% identity in 793 aa overlap. Similar in part, to protein kinases from Myxococcus xanthus e.g. pkn12, serine/threonine protein kinase, TR:Q9XBP5 (EMBL:AF159692) (465 aa); Fasta score E(): 2.9e-10, 28.4% identity in 292 aa o [...]
    
 
 0.721
ML2699
Putative secreted protein; Similar to Mycobacterium tuberculosis hypothetical 83.9 kda protein TR:O05436 (EMBL:Z94121) fasta scores: E(): 0, 72.4% in 803 aa. Contains a possible N-terminal signal sequence.
  
     0.714
ML0081
Putative membrane protein; Similar to M. tuberculosis Rv3835c, hypothetical protein, TR:P96243 (EMBL:AL123456) (449 aa); Fasta score E(): 0, 69.4% identity in 457 aa overlap. Contains hydrophobic, possible membrane-spanning region near the N-terminus.
  
     0.689
ML0256
Putative membrane protein; Similar to M. tuberculosis Rv1024, hypothetical protein, TR:P96376 (EMBL:AL123456) (228 aa); Fasta score E(): 0, 70.5% identity in 220 aa overlap. Contains hydrophobic, possible membrane-spanning region.
  
     0.680
ML0007
Putative membrane protein; Similar to M. tuberculosis Rv0007, hypothetical protein, TR:P71575 (EMBL:AL123456) (304 aa); Fasta score E(): 0, 53.8% identity in 316 aa overlap. Previously sequenced as TR:O32870 (EMBL:Z70722) (303 aa); Fasta score E(): 0, 99.7% identity in 303 aa overlap. Contains hydrophobic, possible membrane-spanning regions; Contains a region identical to ML2630.
  
    0.640
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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