STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML2647Putative peptide methionine sulfoxide; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. (177 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
  
  
 0.818
thiX
Thiredoxin; Similar to Mycobacterium tuberculosis putative thioredoxin TR:O53828 (EMBL:AL022004) fasta scores: E(): 1.1e-30, 63.8% in 141 aa, and to Anacystis nidulans thioredoxin 1 SW:THI1_ANANI (P12243) fasta scores: E(): 9e-07, 37.6% in 93 aa. Contains PS00194 Thioredoxin family active site; Similar to and ML2703.
   
 0.807
ML2300
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical protein Rv3673c or MTV025.021C TR:O69641 (EMBL:AL022121) (227 aa) fasta scores: E(): 0, 71.2% id in 215 aa. Shows weak similarity to Bacillus subtilis ResA protein resA SW:RESA_BACSU (P35160) (181 aa) fasta scores: E(): 5e-06, 31.6% id in 114 aa and to thioredoxins. Contains hydrophobic, possible membrane-spanning region. Contains PS00194 Thioredoxin family active site.
   
 0.807
ML2412
Similar to Mycobacterium tuberculosis hypothetical protein Rv0526 TR:O06392 (EMBL:Z95558) (216 aa) fasta scores: E(): 0, 78.5% id in 214 aa.
   
 0.807
tyrS
tyrosyl-tRNA synthase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.
    
 0.758
nrdH
Highly similar to many glutaredoxin-like proteins involved in electron transport for the ribonucleotide reductase system NrdEF, including: Escherichia coli SW:NRDH_ECOLI (Q47414) (81 aa); Fasta score E(): 1.1e-11, 44.0% identity in 75 aa overlap and Mycobacterium tuberculosis RV3053C TR:P95106 (EMBL:Z83866) (79 aa); Fasta score E(): 7.7e-31, 91.1% identity in 79 aa overlap.
  
 
 0.706
trxB-2
Bifunctional thioredoxin reductase/thioredoxin; EC_number=EC 1.6.4.5; Previously sequenced and characterised: Mycobacterium leprae bifunctional thioredoxin reductase/thioredoxin [includes: thioredoxin reductase SW:TRXB_MYCLE (P46843) fasta scores: E(): 0, 100.0% in 458 aa. Contains Pfam match to entry PF00085 thiored, Thioredoxin. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. Contains PS00194 Thioredoxin family active site.
  
  
 0.551
lpd
Dihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. Catalyzes the reoxidation of dihydrolipoyl groups which are covalently attached to the lipoate acyltransferase components (E2) of the complexes (By similarity); Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
  
  
 0.504
ML1492
Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family.
      
 0.486
metH
5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).
  
  
 0.466
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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