STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
moeAPutative molybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (424 aa)    
Predicted Functional Partners:
moaB
Similar to M.tuberculosis moaB2, putative molybdenum cofactor biosynthesis protein, TR:O53897 (EMBL:AL123456) (181 aa); Fasta score E(): 0, 92.7% identity in 179 aa overlap. Similar to many e.g. to the C-terminal halves of Arabidopsis thaliana cnx1, multifunctional two-domain protein involved in molybdenum cofactor biosynthesis, SW:CNX1_ARATH (Q39054) (670 aa); Fasta score E(): 7.7e-10, 36.4% identity in 187 aa overlap and Synechococcus sp. (strain PCC 7942) moaCB, molybdenum cofactor biosynthesis protein, SW:MOCB_SYNP7 (Q56208) (319 aa); Fasta score E(): 1.3e-09, 35.9% identity in 142 [...]
 
 
 0.888
rimJ
Similar to M.tuberculosis rimJ, Rv0995, possible acetyltransferase, TR:O05578 (EMBL:AL123456) (203 aa); Fasta score E(): 0, 86.0% identity in 200 aa overlap. Similar to Escherichia coli rimJ, ribosomal-protein-alanine acetyltransferase, SW:RIMJ_ECOLI (P09454) (194 aa); Fasta score E(): 9.4e-12, 28.0% identity in 189 aa overlap and to other putative acetyltransferases. Previously sequenced as TR:Q9Z5F9 (EMBL:AL035500) (218 aa); Fasta score E(): 0, 100.0% identity in 214 aa overlap. Contains Pfam match to entry PF00583 Acetyltransf, Acetyltransferase (GNAT) family.
  
    0.818
galU
Similar to M.tuberculosis galU, Rv0993, UTP-glucose-1-phosphate uridylyltransferase, TR:O05576 (EMBL:AL123456) (306 aa); Fasta score E(): 0, 89.7% identity in 302 aa overlap. Similar to many e.g. Escherichia coli galU, UTP--glucose-1-phosphate uridylyltransferase, SW:GALU_ECOLI (P25520) (301 aa); Fasta score E(): 5.4e-33, 38.8% identity in 299 aa overlap. Previously sequenced as TR:Q9Z5G1 (EMBL:AL035500) (306 aa); Fasta score E(): 0, 100.0% identity in 306 aa overlap. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase.
       0.744
ML0185
Putative membrane protein; Similar to M.tuberculosis Rv0996, hypothetical protein, TR:O05579 (EMBL:AL123456) (358 aa); Fasta score E(): 0, 66.4% identity in 360 aa overlap. Previously sequenced as TR:Q9Z5F8 (EMBL:AL035500) (342 aa); Fasta score E(): 0, 100.0% identity in 342 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
 
     0.720
moeZ
Probably involved in molybdopterin biosynthesis; Similar to M. tuberculosis moeZ, Rv3206c, moeB homologue, TR:O05860 (EMBL:AL123456) (392 aa); Fasta score E(): 0, 86.4% identity in 391 aa overlap and to M. tuberculosis moeB, Rv3116, putative molybdopterin biosynthesis protein, TR:O05792 (EMBL:AL123456) (389 aa); Fasta score E(): 0, 57.8% identity in 384 aa overlap. Similar to many e.g. Arabidopsis thaliana cnx5, molybdopterin synthase sulphurylase, TR:Q9ZNW0 (EMBL:AF124160) (464 aa); Fasta score E(): 0, 34.5% identity in 406 aa overlap. Contains Pfam match to entry PF00581 Rhodanese, R [...]
 
  
 0.696
ML0181
Similar to M.tuberculosis Rv0992c, conserved hypothetical protein, TR:O05575 (EMBL:AL123456) (197 aa); Fasta score E(): 0, 72.6% identity in 197 aa overlap. Similar to many hypothetical proteins and shows weak similarity to methenyltetrahydrofolate synthetases e.g. human mthfs, 5-formyltetrahydrofolate cyclo-ligase, SW:FTHC_HUMAN (P49914) (202 aa); Fasta score E(): 7e-06, 23.3% identity in 189 aa overlap. Previously sequenced as TR:Q9Z5G2 (EMBL:AL035500) (197 aa); Fasta score E(): 0, 100.0% identity in 197 aa overlap. Contains Pfam match to entry PF01812 5-FTHF_cyc-lig, 5-formyltetrahy [...]
     
 0.677
ML0180
Similar to M.tuberculosis Rv0991c, hypothetical protein with Ser-rich C-terminus, TR:O05574 (EMBL:AL123456) (110 aa); Fasta score E(): 1.1e-23, 78.5% identity in 93 aa overlap. Similar to other bacterial Ser-rich hypothetical proteins e.g. Streptomyces coelicolor SCE22.04, hypothetical protein, TR:CAB90971 (EMBL:AL355832) (110 aa); Fasta score E(): 2.6e-15, 54.5% identity in 99 aa overlap. Previously sequenced as TR:Q9Z5G3 (EMBL:AL035500) (120 aa); Fasta score E(): 1.1e-32, 100.0% identity in 99 aa overlap.
       0.603
gcvB
Glycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
    0.518
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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