STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0202Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. (405 aa)    
Predicted Functional Partners:
dnaN
Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...]
 
 0.999
ML0603
Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
  
 
 0.999
dnaE
DNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.
  
 
 0.998
dnaZX
DNA polymerase III, subunit [gamma/tau]; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 
0.998
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
   
 0.960
topA
Putative DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...]
 
 0.771
ML1119
Hypothetical protein; Highly similar, in parts,to Mycobacterium tuberculosis hypothetical protein Rv1277 TR:Q50699 (EMBL:Z77137) (417 aa); Fasta score E(): 0, 82.0% identity in 383 aa overlap.
   
 0.717
tmk
Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.694
ML0055
Conserved hypothetical protein; Part of the ESX-1 / type VII specialized secretion system (T7SS), which exports several proteins including EsxA and EsxB. EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (By similarity).
   
  0.686
ML2537
Conserved hypothetical protein; Part of an ESX-3 / type VII specialized secretion system (T7SS), which exports several proteins. EccA3 exhibits ATPase activity and may provide energy for the export of ESX-3 substrates (By similarity).
   
  0.686
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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