STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folKSimilar to M. tuberculosis folK, Rv3607c, probable 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase, SW:HPPK_MYCTU (O06276) (188 aa); Fasta score E(): 0, 63.2% identity in 190 aa overlap. Similar to others e.g. to the C-terminal half of Streptococcus pneumoniae sulD, bifunctional folate synthesis protein (includes: dihydroneopterin aldolase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase), SW:SULD_STRPN (P22291) (270 aa); Fasta score E(): 1.8e-07, 37.8% identity in 135 aa overlap. Previously sequenced as SW:HPPK_MYCLE (O69528) (191 aa); Fasta sc [...] (191 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives.
 
 
 0.999
folB
Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin, 7,8-dihydromonapterin and 7,8- dihydroxanthopterin, respectively, in equal quantities. After longer incubation times the only product is 6-hydroxymethyl-7,8-dihydropterin.
 
 0.999
folP2
Dihydropteroate synthase; Has very low affinity for the DHPS substrate 6-hydroxymethyl- 7,8-dihydropterin-pyrophosphate, but can bind the inhibitor dapsone. Seems to lack dihydropteroate synthase activity, and does probably not function in folate metabolism (By similarity).
 
 
 0.995
folE
Similar to M. tuberculosis folE, Rv3609c, GTP cyclohydrolase I, SW:GCH1_MYCTU (O06273) (202 aa); Fasta score E(): 0, 82.0% identity in 205 aa overlap. Similar to many e.g. Bacillus subtilis mtrA, GTP cyclohydrolase I, SW:GCH1_BACSU (P19465) (190 aa); Fasta score E(): 0, 59.5% identity in 190 aa overlap. Previously sequenced as SW:GCH1_MYCLE (O69531) (205 aa); Fasta score E(): 0, 100.0% identity in 205 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 GTP cyclohydrolase I signature 2.
 
  
 0.991
ML0227
Putative membrane protein; Similar to M. tuberculosis Rv3605c, hypothetical protein, TR:O06277 (EMBL:AL123456) (158 aa); Fasta score E(): 0, 85.4% identity in 158 aa overlap. Previously sequenced as TR:O69527 (EMBL:AL023093) (158 aa); Fasta score E(): 0, 100.0% identity in 158 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
       0.859
ftsH
Putative integral membrane peptidase; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family.
  
  
 0.847
ML0228
Putative membrane protein; Similar to M. tuberculosis Rv3604c, putative membrane protein, TR:O06278 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 59.7% identity in 432 aa overlap. Previously sequenced as TR:O69526 (EMBL:AL023093) (432 aa); Fasta score E(): 0, 100.0% identity in 432 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
       0.713
folC
Highly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2.
 
  
 0.603
rpsD
30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
      
 0.556
ribA
Putative GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.547
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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