node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML2502 | fum | gene:17576366 | gene:17575799 | Similar to Mycobacterium tuberculosis probable aspartate aminotransferase RV0337C SW:AAT_MYCTU (O33267) fasta scores: E(): 0, 91.4% id in 429 aa and to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) fasta scores: E(): 0, 32.4% id in 389 aa. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.825 |
ML2502 | sdhA | gene:17576366 | gene:17574521 | Similar to Mycobacterium tuberculosis probable aspartate aminotransferase RV0337C SW:AAT_MYCTU (O33267) fasta scores: E(): 0, 91.4% id in 429 aa and to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) fasta scores: E(): 0, 32.4% id in 389 aa. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. | Similar to M. tuberculosis sdhA, Rv3318, succinate dehydrogenase subunit A, TR:O53370 (EMBL:AL123456) (590 aa); Fasta score E(): 0, 92.5% identity in 590 aa overlap. Similar to many e.g. Escherichia coli sdhA, succinate dehydrogenase flavoprotein subunit, SW:DHSA_ECOLI (P10444) (588 aa); Fasta score E(): 0, 48.6% identity in 589 aa overlap. Previously sequenced as TR:Q49924 (EMBL:U00022) (401 aa); Fasta score E(): 0, 97.2% identity in 395 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD [...] | 0.812 |
ML2502 | sdhB | gene:17576366 | gene:17574520 | Similar to Mycobacterium tuberculosis probable aspartate aminotransferase RV0337C SW:AAT_MYCTU (O33267) fasta scores: E(): 0, 91.4% id in 429 aa and to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) fasta scores: E(): 0, 32.4% id in 389 aa. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. | Similar to M. tuberculosis sdhB, Rv3319, succinate dehydrogenase subunit B, TR:O53371 (EMBL:AL123456) (263 aa); Fasta score E(): 0, 89.8% identity in 264 aa overlap. Similar to many e.g. Escherichia coli sdhB, succinate dehydrogenase iron-sulfur protein, SW:DHSB_ECOLI (P07014) (238 aa); Fasta score E(): 0, 42.9% identity in 240 aa overlap. Previously sequenced as TR:Q49916 (EMBL:U00022) (264 aa); Fasta score E(): 0, 100.0% identity in 264 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur b [...] | 0.806 |
ML2502 | sdhC | gene:17576366 | gene:17574523 | Similar to Mycobacterium tuberculosis probable aspartate aminotransferase RV0337C SW:AAT_MYCTU (O33267) fasta scores: E(): 0, 91.4% id in 429 aa and to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) fasta scores: E(): 0, 32.4% id in 389 aa. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. | Similar to M. tuberculosis sdhC, Rv3316, putative membrane anchor of succinate dehydrogenase, TR:O53368 (EMBL:AL123456) (112 aa); Fasta score E(): 0, 88.4% identity in 112 aa overlap. Similar to many e.g. Escherichia coli sdhC, succinate dehydrogenase cytochrome B-556, SW:DHSC_ECOLI (P10446) (129 aa); Fasta score E(): 0.074, 24.3% identity in 136 aa overlap. Previously sequenced as TR:Q49919 (EMBL:U00022) (244 aa); Fasta score E(): 0, 100.0% identity in 153 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochrome b subunit. | 0.801 |
ML2502 | sdhD | gene:17576366 | gene:17574522 | Similar to Mycobacterium tuberculosis probable aspartate aminotransferase RV0337C SW:AAT_MYCTU (O33267) fasta scores: E(): 0, 91.4% id in 429 aa and to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) fasta scores: E(): 0, 32.4% id in 389 aa. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. | Similar to M. tuberculosis sdhD, Rv3317, putative membrane anchor of succinate dehydrogenase, TR:O53369 (EMBL:AL123456) (144 aa); Fasta score E(): 0, 85.2% identity in 142 aa overlap. Shows weak similarity to e.g. Rickettsia prowazekii sdhD, succinate dehydrogenase hydrophobic membrane anchor protein, SW:DHSD_RICPR (P41086) (125 aa); Fasta score E(): 0.24, 26.7% identity in 105 aa overlap. Previously sequenced as TR:Q49915 (EMBL:U00022) (163 aa); Fasta score E(): 0, 100.0% identity in 163 aa overlap.Contains hydrophobic, possible membrane-spanning regions. | 0.800 |
argH | fum | gene:17575252 | gene:17575799 | Arginosuccinate lyase; Highly similar to many argininosuccinate lyases (EC 4.3.2.1) involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa); BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa); Fasta score E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature. | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 0.815 |
argH | sdhA | gene:17575252 | gene:17574521 | Arginosuccinate lyase; Highly similar to many argininosuccinate lyases (EC 4.3.2.1) involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa); BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa); Fasta score E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature. | Similar to M. tuberculosis sdhA, Rv3318, succinate dehydrogenase subunit A, TR:O53370 (EMBL:AL123456) (590 aa); Fasta score E(): 0, 92.5% identity in 590 aa overlap. Similar to many e.g. Escherichia coli sdhA, succinate dehydrogenase flavoprotein subunit, SW:DHSA_ECOLI (P10444) (588 aa); Fasta score E(): 0, 48.6% identity in 589 aa overlap. Previously sequenced as TR:Q49924 (EMBL:U00022) (401 aa); Fasta score E(): 0, 97.2% identity in 395 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD [...] | 0.809 |
argH | sdhB | gene:17575252 | gene:17574520 | Arginosuccinate lyase; Highly similar to many argininosuccinate lyases (EC 4.3.2.1) involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa); BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa); Fasta score E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature. | Similar to M. tuberculosis sdhB, Rv3319, succinate dehydrogenase subunit B, TR:O53371 (EMBL:AL123456) (263 aa); Fasta score E(): 0, 89.8% identity in 264 aa overlap. Similar to many e.g. Escherichia coli sdhB, succinate dehydrogenase iron-sulfur protein, SW:DHSB_ECOLI (P07014) (238 aa); Fasta score E(): 0, 42.9% identity in 240 aa overlap. Previously sequenced as TR:Q49916 (EMBL:U00022) (264 aa); Fasta score E(): 0, 100.0% identity in 264 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur b [...] | 0.812 |
argH | sdhC | gene:17575252 | gene:17574523 | Arginosuccinate lyase; Highly similar to many argininosuccinate lyases (EC 4.3.2.1) involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa); BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa); Fasta score E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature. | Similar to M. tuberculosis sdhC, Rv3316, putative membrane anchor of succinate dehydrogenase, TR:O53368 (EMBL:AL123456) (112 aa); Fasta score E(): 0, 88.4% identity in 112 aa overlap. Similar to many e.g. Escherichia coli sdhC, succinate dehydrogenase cytochrome B-556, SW:DHSC_ECOLI (P10446) (129 aa); Fasta score E(): 0.074, 24.3% identity in 136 aa overlap. Previously sequenced as TR:Q49919 (EMBL:U00022) (244 aa); Fasta score E(): 0, 100.0% identity in 153 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochrome b subunit. | 0.800 |
argH | sdhD | gene:17575252 | gene:17574522 | Arginosuccinate lyase; Highly similar to many argininosuccinate lyases (EC 4.3.2.1) involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa); BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa); Fasta score E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature. | Similar to M. tuberculosis sdhD, Rv3317, putative membrane anchor of succinate dehydrogenase, TR:O53369 (EMBL:AL123456) (144 aa); Fasta score E(): 0, 85.2% identity in 142 aa overlap. Shows weak similarity to e.g. Rickettsia prowazekii sdhD, succinate dehydrogenase hydrophobic membrane anchor protein, SW:DHSD_RICPR (P41086) (125 aa); Fasta score E(): 0.24, 26.7% identity in 105 aa overlap. Previously sequenced as TR:Q49915 (EMBL:U00022) (163 aa); Fasta score E(): 0, 100.0% identity in 163 aa overlap.Contains hydrophobic, possible membrane-spanning regions. | 0.800 |
fum | ML2502 | gene:17575799 | gene:17576366 | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Similar to Mycobacterium tuberculosis probable aspartate aminotransferase RV0337C SW:AAT_MYCTU (O33267) fasta scores: E(): 0, 91.4% id in 429 aa and to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) fasta scores: E(): 0, 32.4% id in 389 aa. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. | 0.825 |
fum | argH | gene:17575799 | gene:17575252 | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Arginosuccinate lyase; Highly similar to many argininosuccinate lyases (EC 4.3.2.1) involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa); BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa); Fasta score E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature. | 0.815 |
fum | gabD | gene:17575799 | gene:17576439 | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Succinate-semialdehyde dehydrogenase; Catalyzes the NADP(+)-dependent oxidation of succinate semialdehyde to succinate. It is believed to be the main source of succinate semialdehyde dehydrogenase activity in Mycobacterium (By similarity). | 0.848 |
fum | odhA | gene:17575799 | gene:17574921 | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | 2-oxoglutarate dehydrogenase, E1 and E2 components; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxo [...] | 0.739 |
fum | sdhA | gene:17575799 | gene:17574521 | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Similar to M. tuberculosis sdhA, Rv3318, succinate dehydrogenase subunit A, TR:O53370 (EMBL:AL123456) (590 aa); Fasta score E(): 0, 92.5% identity in 590 aa overlap. Similar to many e.g. Escherichia coli sdhA, succinate dehydrogenase flavoprotein subunit, SW:DHSA_ECOLI (P10444) (588 aa); Fasta score E(): 0, 48.6% identity in 589 aa overlap. Previously sequenced as TR:Q49924 (EMBL:U00022) (401 aa); Fasta score E(): 0, 97.2% identity in 395 aa overlap. Contains Pfam match to entry PF00890 FAD_binding_2, FAD binding domain. Contains PS00504 Fumarate reductase / succinate dehydrogenase FAD [...] | 0.995 |
fum | sdhB | gene:17575799 | gene:17574520 | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Similar to M. tuberculosis sdhB, Rv3319, succinate dehydrogenase subunit B, TR:O53371 (EMBL:AL123456) (263 aa); Fasta score E(): 0, 89.8% identity in 264 aa overlap. Similar to many e.g. Escherichia coli sdhB, succinate dehydrogenase iron-sulfur protein, SW:DHSB_ECOLI (P07014) (238 aa); Fasta score E(): 0, 42.9% identity in 240 aa overlap. Previously sequenced as TR:Q49916 (EMBL:U00022) (264 aa); Fasta score E(): 0, 100.0% identity in 264 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur b [...] | 0.956 |
fum | sdhC | gene:17575799 | gene:17574523 | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Similar to M. tuberculosis sdhC, Rv3316, putative membrane anchor of succinate dehydrogenase, TR:O53368 (EMBL:AL123456) (112 aa); Fasta score E(): 0, 88.4% identity in 112 aa overlap. Similar to many e.g. Escherichia coli sdhC, succinate dehydrogenase cytochrome B-556, SW:DHSC_ECOLI (P10446) (129 aa); Fasta score E(): 0.074, 24.3% identity in 136 aa overlap. Previously sequenced as TR:Q49919 (EMBL:U00022) (244 aa); Fasta score E(): 0, 100.0% identity in 153 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochrome b subunit. | 0.946 |
fum | sdhD | gene:17575799 | gene:17574522 | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | Similar to M. tuberculosis sdhD, Rv3317, putative membrane anchor of succinate dehydrogenase, TR:O53369 (EMBL:AL123456) (144 aa); Fasta score E(): 0, 85.2% identity in 142 aa overlap. Shows weak similarity to e.g. Rickettsia prowazekii sdhD, succinate dehydrogenase hydrophobic membrane anchor protein, SW:DHSD_RICPR (P41086) (125 aa); Fasta score E(): 0.24, 26.7% identity in 105 aa overlap. Previously sequenced as TR:Q49915 (EMBL:U00022) (163 aa); Fasta score E(): 0, 100.0% identity in 163 aa overlap.Contains hydrophobic, possible membrane-spanning regions. | 0.911 |
fum | sucC | gene:17575799 | gene:17573970 | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | succinyl-CoA synthase [beta] chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.756 |
fum | sucD | gene:17575799 | gene:17573971 | Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. | succinyl-CoA synthase [alpha] chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.650 |