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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1053Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49943 (EMBL:U15180) (99 aa); Fasta score E(): 0, 100.0% identity in 99 aa overlap. Also highly similar to the whole or just the N-terminus of many Mycobacterium tuberculosis PE-family proteins e.g. TR:O53938 (EMBL:AL022021) (99 aa); Fasta score E(): 2e-11, 46.7% identity in 92 aa overlap and TR:P71664 (EMBL:Z80108) (576 aa); Fasta score E(): 3.2e-10, 44.6% identity in 92 aa overlap. (99 aa)    
Predicted Functional Partners:
ML1182
PPE-family protein; Identical to the previously sequenced Mycobacterium leprae putative PPE protein TR:Q9Z5K0 (EMBL:AL049191) (421 aa); Fasta score E(): 0, 100.0% identity in 421 aa overlap. Also highly similar to many members of the Mycobacterium tuberculosis PPE-family of proteins e.g. Rv2892c SW:YS92_MYCTU (Q10813) (408 aa); Fasta score E(): 1.2e-25, 34.0% identity in 429 aa overlap. Contains Pfam match to entry PF00823 PPE, PPE family.
      
 0.683
PE
PE-family protein; Similar to M. tuberculosis PE, Rv1386, PE-family protein, SW:YD86_MYCTU (P71656) (102 aa); Fasta score E(): 2.8e-25, 72.5% identity in 102 aa overlap; Similar to ML452, ML1183 and ML2129.
      
 0.682
PPE-2
PPE-family protein; Similar to Mycobacterium tuberculosis PPE-family proteins e.g. Rv0256c or MTV034.22C TR:O53678 (EMBL:AL021929) (556 aa) fasta scores: E(): 0, 63.5% id in 564 aa. Previously sequenced as TR:O33009 (EMBL:Z98756). Contains Pfam match to entry PF00823 PPE, PPE family.
      
 0.682
PPE-3
PPE-family protein; Similar to M. tuberculosis PPE-family protein Rv0096 SW:Y096_MYCTU (Q10892) (463 aa); Fasta score E(): 0, 58.6% identity in 466 aa overlap. Contains Pfam match to entry PF00823 PPE, PPE family; Similar to ML1828 and ML0539.
      
 0.682
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.