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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1221Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49616 (EMBL:U00010) (80 aa); Fasta score E(): 0, 98.8% identity in 80 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1590 TR:O06600 (EMBL:Z95586) (79 aa); Fasta score E(): 3.4e-21, 67.1% identity in 73 aa overlap; To M.tuberculosis Rv1590. (80 aa)    
Predicted Functional Partners:
bioB
Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
  
 0.906
ML1222
Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49626 (EMBL:U00010) (198 aa); Fasta score E(): 0, 99.5% identity in 198 aa overlap. Highly similar to proteins of undefined function also found downstream of BioB orthologues in Mycobacterium tuberculosis Rv1591 TR:O06599 (EMBL:Z95586) (221 aa); Fasta score E(): 0, 63.8% identity in 188 aa overlap and Mycobacterium bovis BCG TR:O52590 (EMBL:AF041819) (193 aa); Fasta score E(): 0, 67.6% identity in 170 aa overlap.
       0.859
ML0806
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 14.3 kDa protein Rv3217c or MTCY07D11.09 TR:O05849 (EMBL:Z95120) fasta scores: E(): 0, 77.1% id in 140 aa. Contains hydrophobic, possible membrane-spanning regions.
  
     0.709
ML0834
Similar to Mycobacterium tuberculosis hypothetical protein Rv2342 or MTCY98.11 TR:P95238 (EMBL:Z83860) (85 aa) fasta scores: E(): 3e-21, 76.9% id in 78 aa and shows weak similarity to Streptomyces coelicolor putative secreted protein SCC24.32 TR:CAB86126 (EMBL:AL163003) (108 aa) fasta scores: E(): 0.035, 30.5% id in 95 aa.
  
     0.630
ML0096
Putative membrane protein; Similar to M. tuberculosis Rv3805c, possible membrane protein, TR:O53582 (EMBL:AL123456) (627 aa); Fasta score E(): 0, 80.9% identity in 629 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
  
     0.579
ML2454
Possible hemagglutinin; Might mediate adherence to host cells by binding sulfated glycoconjugates.
  
     0.553
ML0099
Similar to M. tuberculosis Rv3802c, hypothetical protein, TR:O53581 (EMBL:AL123456) (336 aa); Fasta score E(): 0, 75.5% identity in 335 aa overlap.
  
     0.542
ML2390
Possible secreted protein; Similar to Mycobacterium tuberculosis hypothetical protein Rv1083 TR:O53431 (EMBL:AL021897) (88 aa) fasta scores: E(): 4.9e-15, 57.4% id in 101 aa. Contains a possible N-terminal signal sequence.
  
     0.525
ML0888
Conserved hypothetical protein; Previously sequenced Mycobacterium leprae hypothetical protein TR:O69576 (EMBL:AL022602) (135 aa); Fasta score E(): 0, 100.0% identity in 135 aa overlap(EMBL:AL022602). Also similar to Mycobacterium tuberculosis hypothetical protein TR:O53520 (EMBL:AL021957) (129 aa); Fasta score E(): 0, 80.0% identity in 130 aa overlap(EMBL:AL021957).
  
     0.511
ML2135
Possible transmembrane protein; Similar to Mycobacterium tuberculosis hypothetical 39.8 kda protein rv0885 SW:Y885_MYCTU (Q10546) fasta scores: E(): 0, 83.9% in 341 aa, and to Streptomyces coelicolor putative membrane protein TR:Q9XAE8 (EMBL:AL079356) fasta scores: E(): 1.5e-13, 27.1% in 255 aa. Contains possible membrane spanning hydrophobic domains.
  
     0.509
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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