STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity). (289 aa)    
Predicted Functional Partners:
hisE
Highly similar to several phosphoribosyl-ATP pyrophosphatases (EC 3.6.1.31) involved in histidine biosynthesis, including: Sulfolobus solfataricus HisE SW:HIS2_SULSO (O33776) (94 aa); Fasta score E(): 0.00013, 32.5% identity in 83 aa overlap and Mycobacterium tuberculosis RV2122C SW:HIS2_MYCTU (O33257) (93 aa); Fasta score E(): 2.5e-31, 86.0% identity in 93 aa overlap. Contains Pfam match to entry PF01503 PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase.
 
 
 0.999
hisB
Highly similar to many imidazoleglycerol-phosphate dehydratases (EC 4.2.1.19) involved in histidine biosynthesis e.g. from Mycobacterium tuberculosis RV1601 SW:HIS7_MYCTU (O06590) (210 aa); Fasta score E(): 0, 84.8% identity in 210 aa overlap and Streptomyces coelicolor SW:HIS7_STRCO (P16247) (197 aa); Fasta score E(): 0, 56.4% identity in 202 aa overlap. Contains 2 Pfam matches to entry PF00475 IGPD, Imidazoleglycerol-phosphate dehydratase. Contains PS00955 Imidazoleglycerol-phosphate dehydratase signature 2. Contains PS00954 Imidazoleglycerol-phosphate dehydratase signature 1.
 
  
 0.994
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
  
 0.988
hisF
Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
 
  
 0.973
hisH
Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
 
  
 0.972
hisC
Highly similar to many histidinol-phosphate aminotransferases (EC 2.6.1.9) involved in histidine biosynthesis e.g. Mycobacterium tuberculosis RV1600 TR:SW:HIS8_MYCTU (O06591) (380 aa); Fasta score E(): 0, 83.6% identity in 366 aa overlap and Mycobacterium smegmatis SW:HIS8_MYCSM (P28735) (219 aa); Fasta score E(): 0, 77.2% identity in 219 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II.
 
  
 0.970
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family.
 
  
 0.970
hisI
phosphoribosyl-AMP 1,6 cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
 
  
 0.961
prsA
Putative ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.837
hisS
histidyl-tRNA synthase; Similar to M. tuberculosis hisS, Rv2580c, histidyl-tRNA synthase, SW:SYH_MYCTU (Q50641) (423 aa); Fasta score E(): 0, 85.9% identity in 417 aa overlap. Similar to many e.g. Escherichia coli hisS, histidyl-tRNA synthase, SW:SYH_ECOLI (P04804) (423 aa); Fasta score E(): 0, 42.1% identity in 413 aa overlap. Previously sequenced as SW:SYH_MYCLE (P46696) (427 aa); Fasta score E(): 0, 99.5% identity in 427 aa overlap. Contains Pfam match to entry PF00587 tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T). Contains PS00017 ATP/GTP-binding site motif A (P-loop). [...]
  
 
 0.752
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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