STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1505Conserved hypothetical Proline rich protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV1158C TR:O06556 (EMBL:Z95584) (227 aa); Fasta score E(): 1.1e-16, 51.7% identity in 236 aa overlap. Note the predicted product of this CDS is rich in the amino acids Pro and Ala and displays multiple ProAla repeats. (182 aa)    
Predicted Functional Partners:
ML1506
Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV1157C TR:O06555 (EMBL:Z95584) (371 aa); Fasta score E(): 0, 68.0% identity in 369 aa overlap. Note the predicted product of this CDS is rich in the amino acids Pro.
 
  
 0.952
ML1504
Probable conserved membrane protein; Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis possible membrane protein RV1159 TR:O06557 (EMBL:Z95584) (431 aa); Fasta score E(): 0, 75.7% identity in 420 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
 
    0.880
ML0228
Putative membrane protein; Similar to M. tuberculosis Rv3604c, putative membrane protein, TR:O06278 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 59.7% identity in 432 aa overlap. Previously sequenced as TR:O69526 (EMBL:AL023093) (432 aa); Fasta score E(): 0, 100.0% identity in 432 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
  
     0.758
gpsI
Putative polyribonucleotide phosphorylase / guanosine pentaphosphate synthetase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
  
 
 0.739
ML0127
Hypothetical protein; Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p- hydroxybenzoic acid derivatives (p-HBAD).
  
     0.731
ML0893
Probable conserved integral membrane protein; Identical to the previously sequenced Mycobacterium leprae putative integral membrane protein TR:O69571 (EMBL:AL022602) (428 aa); Fasta score E(): 0, 100.0% identity in 428 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis putative membrane protein TR:O53515 (EMBL:AL021957) (427 aa); Fasta score E(): 0, 80.0% identity in 431 aa overlap(EMBL:AL021957). Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence.
  
     0.729
ML1751
Conserved hypothetical protein; Similar to several proteins of undefined function e.g. Mycobacterium tuberculosis SW:YD55_MYCTU (Q11025) (715 aa); Fasta score E(): 0, 57.3% identity in 705 aa overlap. Contains Pfam match to entry PF00899 ThiF_family, ThiF family.
  
     0.705
ML1182
PPE-family protein; Identical to the previously sequenced Mycobacterium leprae putative PPE protein TR:Q9Z5K0 (EMBL:AL049191) (421 aa); Fasta score E(): 0, 100.0% identity in 421 aa overlap. Also highly similar to many members of the Mycobacterium tuberculosis PPE-family of proteins e.g. Rv2892c SW:YS92_MYCTU (Q10813) (408 aa); Fasta score E(): 1.2e-25, 34.0% identity in 429 aa overlap. Contains Pfam match to entry PF00823 PPE, PPE family.
      
 0.682
ML0159
Putative membrane protein; Similar to M. tuberculosis Rv0955, possible membrane protein, SW:Y955_MYCTU (P71555) (455 aa); Fasta score E(): 0, 75.9% identity in 419 aa overlap. Previously sequenced as TR:Q9Z5H7 (EMBL:AL035500) (430 aa); Fasta score E(): 0, 99.8% identity in 430 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
  
     0.681
ML0042
Putative membrane protein; Similar to M. tuberculosis Rv3882c, conserved hypothetical protein, TR:O05462 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 72.1% identity in 462 aa overlap. Shows weak similarity to M.tuberculosis Rv3885c, hypothetical protein, TR:O05459 (EMBL:AL123456) (537 aa); Fasta score E(): 3.1e-09, 28.0% identity in 382 aa overlap. Previously sequenced as TR:O33077 (EMBL:Y14967) (467 aa); Fasta score E(): 0, 100.0% identity in 467 aa overlap. Contains hydrophobic, possible membrane-spanning regions near the N-terminus; Shows weak similarity to ML1537.
  
     0.680
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.