STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
xerCIntegrase/recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (297 aa)    
Predicted Functional Partners:
ML0776
ML0776 protein; Similar to the N-terminal half of Mycobacterium tuberculosis hypothetical 22.5 kDa protein RV3242C OR MTCY20B11.17C TR:O05887 (EMBL:Z95121) fasta scores: E(): 6.8e-18, 78.1% id in 64 aa.
   
    0.882
ML1439
Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.
      
 0.829
ML0513
Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.
   
  
 0.705
ML2472
Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase.
  
    0.698
ML0565
Putative transcriptional regulator; Involved in cell division and chromosome segregation.
   
    0.690
ML0793
Putative bacteriophage protein; Similar to Mycobacterium tuberculosis hypothetical 27.6 kDa protein RV3226C OR MTCY20B11.01C TR:O05872 (EMBL:Z95121) fasta scores: E(): 0, 70.6% id in 252 aa, and to Bacteriophage SPBc2 yoqW protein TR:O64131 (EMBL:AF020713) fasta scores: E(): 4.8e-21, 36.5% id in 244 aa; Belongs to the SOS response-associated peptidase family.
   
    0.690
arsC
Putative arsenate reductase; Similar to many e.g. Escherichia coli arsC, arsenate reductase, SW:ARC1_ECOLI (P08692) (141 aa); Fasta score E(): 1.7e-07, 38.8% identity in 103 aa overlap. Similar to proteins which expand the substrate specificity of arsAB pump.
      
 0.681
ftsK
Cell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Belongs to the FtsK/SpoIIIE/SftA family.
  
   
 0.618
xseA
Exonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family.
 
  
 0.574
murG
Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
  
  
 0.523
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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