STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML1638Conserved hypothetical protein; Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis RV2229C SW:YM29_MYCTU (Q10513) (245 aa); Fasta score E(): 0, 60.9% identity in 230 aa overlap. Contains a possible coiled-coil between residues 100..139. (232 aa)    
Predicted Functional Partners:
ML1637
Conserved hypothetical protein; Similar in parts to many. The N-terminus is similar to several ribonucleases e.g. Escherichia coli ribonuclease HI (EC 3.1.26.4) SW:RNH_ECOLI (P00647) (430 aa); BlastP Expect 8.7. The C-terminus is similar to many proteins belonging to the phosphoglycerate mutase family e.g. Escherichia coli SW:COBC_ECOLI (P52086) (430 aa); BlastP Expect 8.7. Similar over the whole range to Mycobacterium tuberculosis hypothetical protein RV2228C SW:YM28_MYCTU (Q10512) (364 aa); Fasta score E(): 0, 76.8% identity in 371 aa overlap. Contains Pfam match to entry PF00300 PGA [...]
  
  
 0.976
ML1639
Conserved hypothetical protein; Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis RV2230C SW:YM30_MYCTU (Q10514) (379 aa); Fasta score E(): 0, 79.5% identity in 385 aa overlap. Contains Pfam match to entry PF01784 DUF34, Domain of unknown function.
  
  
 0.965
ML1706
Conserved hypothetical protein; Highly similar to proteins of undefined function from Streptomyces coelicolor TR:Q9Z586 (EMBL:AL035569) (331 aa); Fasta score E(): 0, 38.6% identity in 337 aa overlap and Mycobacterium tuberculosis RV3015C TR:O53262 (EMBL:AL021287) (337 aa); Fasta score E(): 0, 78.3% identity in 337 aa overlap.
  
     0.612
ML0876
Putative membrane protein; Part of cytochrome c oxidase, its function is unknown. Belongs to the cytochrome c oxidase bacterial subunit CtaF family.
  
   
 0.599
ML1652
Conserved hypothetical protein; Highly similar to proteins of unknown function from Streptomyces coelicolor TR:Q9RDP8 (EMBL:AL133423) (401 aa); Fasta score E(): 4.3e-26, 42.0% identity in 383 aa overlap and Mycobacterium tuberculosis RV2242 TR:YM42_MYCTU. Contains a probable helix-turn-helix motif at aa 359-380 (Score 1390, SD +3.92).
  
     0.561
ML1644
Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2235 SW:YM35_MYCTU (Q10517) (271 aa); Fasta score E(): 0, 74.2% identity in 271 aa overlap. Contains a possible N-terminal signal sequence and another possible membrane spanning hydrophobic domain.
 
     0.557
ML1329
Conserved hypothetical protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafB family.
  
     0.546
ML0764
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 35.3 kDa protein RV3256C OR MTV015.01C-MTCY20B11.31C TR:O05899 (EMBL:Z95121) fasta scores: E(): 0, 75.3% id in 365 aa.
 
     0.531
ML0904
Probable membrane protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69562 (EMBL:AL022602) (134 aa); Fasta score E(): 0, 100.0% identity in 134 aa overlap(EMBL:AL022602). Also highly similar to several others e.g. Mycobacterium tuberculosis hypothetical protein TR:O53503 (EMBL:AL021957) (134 aa); Fasta score E(): 0, 86.6% identity in 134 aa overlap(EMBL:AL021957) and Streptomyces coelicolor putative membrane protein TR:Q9XAJ8 (EMBL:AL079348) (96 aa); Fasta score E(): 0.22, 38.3% identity in 60 aa overlap(EMBL:AL079348). Contains a large central [...]
  
     0.529
ML0733
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 19.8 kda protein RV3278C OR MTCY71.18C TR:P96883 (EMBL:Z92771) fasta scores: E(): 0, 83.1% id in 172 aa. Previously sequenced as TR:Q49672 (EMBL:U00012). Contains hydrophobic, possible membrane-spanning regions.
  
    0.490
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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