STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
parAPutative cell division protein; Similar to many proteins thought to be involved with chromosome partitioning e.g. Mycobacterium tuberculosis hypothetical 37.5 kda protein TR:O53596 (EMBL:AL021426) fasta scores: E(): 0, 78.1% in 347 aa, and to Bacillus subtilis soj protein SW:SOJ_BACSU (P37522) fasta scores: E(): 0, 52.6% in 251 aa. Contains Pfam match to entry PF00991 ParA, ParA family ATPase. (351 aa)    
Predicted Functional Partners:
parB
Putative cell division protein; Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication (By similarity).
 
 
 0.995
ML2708
Conserved hypothetical protein; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
  
  
 0.948
ML2709
Conserved hypothetical protein; Similar to Mycobacterium paratuberculosis hypothetical 20.1 kda protein TR:AAF33691 (EMBL:AF222789) fasta scores: E(): 0, 76.0% in 183 aa, and to Mycobacterium tuberculosis hypothetical 20.6 kda protein TR:O53598 (EMBL:AL021426) fasta scores: E(): 0, 73.1% in 193 aa. Contains Pfam match to entry PF01424 R3H, R3H domain.
       0.759
ML2710
Putative conserved membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins (By similarity).
     
 0.696
dnaA
Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).
 
 
 0.663
tagA
DNA-3-methyladenine glycosidase I; Identical to the previously sequenced Mycobacterium leprae TR:Q49957 (EMBL:U15180) (192 aa); Fasta score E(): 0, 99.5% identity in 192 aa overlap. Also highly similar to DNA-3-methyladenine glycosidases from Mycobacterium tuberculosis Rv1210 TR:O05311 (EMBL:Z93777) (204 aa); Fasta score E(): 0, 80.2% identity in 192 aa overlap and Escherichia coli SW:3MG1_ECOLI (P05100) (187 aa); Fasta score E(): 1.8e-27, 43.8% identity in 185 aa overlap.
      
 0.649
rnpA
Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
     
 0.484
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
     
 0.470
ML2705
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 26.6 kda protein Rv3916c TR:O53594 (EMBL:AL021426) fasta scores: E(): 0, 76.4% in 250 aa, and to Streptomyces coelicolor hypothetical 22.6 kda protein TR:Q9R3S2 (EMBL:AF187159) fasta scores: E(): 1e-08, 39.7% in 237 aa.
       0.469
ftsZ
Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
  
 0.454
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.