| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MSC_0187 | gcdH | MSC_0187 | MSC_0529 | Hypothetical transmembrane protein. | Glycine cleavage system H protein. | 0.578 |
| MSC_0187 | pdhA | MSC_0187 | MSC_0265 | Hypothetical transmembrane protein. | Pyruvate dehydrogenase (lipoamide), alpha chain; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.690 |
| MSC_0187 | pdhB | MSC_0187 | MSC_0266 | Hypothetical transmembrane protein. | Pyruvate dehydrogenase (lipoamide), beta chain. | 0.835 |
| MSC_0187 | pdhD | MSC_0187 | MSC_0268 | Hypothetical transmembrane protein. | Dihydrolipoamide dehydrogenase. | 0.781 |
| MSC_0187 | pdhD-2 | MSC_0187 | MSC_0544 | Hypothetical transmembrane protein. | Dihydrolipoamide dehydrogenase. | 0.781 |
| MSC_0187 | prs | MSC_0187 | MSC_0952 | Hypothetical transmembrane protein. | Ribose-phosphate pyrophosphokinase. | 0.680 |
| folD | gcdH | MSC_0758 | MSC_0529 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein. | 0.488 |
| folD | glyA | MSC_0758 | MSC_0894 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
| folD | pdhD | MSC_0758 | MSC_0268 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Dihydrolipoamide dehydrogenase. | 0.962 |
| folD | pdhD-2 | MSC_0758 | MSC_0544 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Dihydrolipoamide dehydrogenase. | 0.921 |
| folD | prs | MSC_0758 | MSC_0952 | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Ribose-phosphate pyrophosphokinase. | 0.597 |
| gcdH | MSC_0187 | MSC_0529 | MSC_0187 | Glycine cleavage system H protein. | Hypothetical transmembrane protein. | 0.578 |
| gcdH | folD | MSC_0529 | MSC_0758 | Glycine cleavage system H protein. | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.488 |
| gcdH | glyA | MSC_0529 | MSC_0894 | Glycine cleavage system H protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.567 |
| gcdH | pdhC | MSC_0529 | MSC_0267 | Glycine cleavage system H protein. | Dihydrolipoamide S-acetyltransferase. | 0.578 |
| gcdH | pdhD | MSC_0529 | MSC_0268 | Glycine cleavage system H protein. | Dihydrolipoamide dehydrogenase. | 0.947 |
| gcdH | pdhD-2 | MSC_0529 | MSC_0544 | Glycine cleavage system H protein. | Dihydrolipoamide dehydrogenase. | 0.834 |
| glyA | folD | MSC_0894 | MSC_0758 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methylenetetrahydrofolate dehydrogenase (NADP+)/ methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.960 |
| glyA | gcdH | MSC_0894 | MSC_0529 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glycine cleavage system H protein. | 0.567 |
| glyA | pdhD | MSC_0894 | MSC_0268 | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydrolipoamide dehydrogenase. | 0.959 |
