node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MYPE1710 | MYPE3150 | gene:10731270 | gene:10731419 | Thioredoxin; Belongs to the thioredoxin family. | Inosine-5'-monophosphate dehydrogenase. | 0.412 |
MYPE1710 | MYPE3790 | gene:10731270 | gene:10731494 | Thioredoxin; Belongs to the thioredoxin family. | ATP-dependent protease binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | 0.464 |
MYPE1710 | MYPE8960 | gene:10731270 | gene:10732018 | Thioredoxin; Belongs to the thioredoxin family. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.454 |
MYPE1710 | MYPE8970 | gene:10731270 | gene:10732019 | Thioredoxin; Belongs to the thioredoxin family. | Heat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.479 |
MYPE1710 | MYPE9490 | gene:10731270 | gene:10732070 | Thioredoxin; Belongs to the thioredoxin family. | HSP70 family molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.494 |
MYPE1710 | MYPE980 | gene:10731270 | gene:10731190 | Thioredoxin; Belongs to the thioredoxin family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.514 |
MYPE1710 | MYPE990 | gene:10731270 | gene:10731191 | Thioredoxin; Belongs to the thioredoxin family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.699 |
MYPE3150 | MYPE1710 | gene:10731419 | gene:10731270 | Inosine-5'-monophosphate dehydrogenase. | Thioredoxin; Belongs to the thioredoxin family. | 0.412 |
MYPE3150 | MYPE3790 | gene:10731419 | gene:10731494 | Inosine-5'-monophosphate dehydrogenase. | ATP-dependent protease binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | 0.558 |
MYPE3150 | MYPE8360 | gene:10731419 | gene:10731958 | Inosine-5'-monophosphate dehydrogenase. | RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.767 |
MYPE3150 | MYPE8960 | gene:10731419 | gene:10732018 | Inosine-5'-monophosphate dehydrogenase. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.501 |
MYPE3150 | MYPE8970 | gene:10731419 | gene:10732019 | Inosine-5'-monophosphate dehydrogenase. | Heat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.661 |
MYPE3150 | MYPE9490 | gene:10731419 | gene:10732070 | Inosine-5'-monophosphate dehydrogenase. | HSP70 family molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.562 |
MYPE3150 | MYPE980 | gene:10731419 | gene:10731190 | Inosine-5'-monophosphate dehydrogenase. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.547 |
MYPE3150 | MYPE9820 | gene:10731419 | gene:10732102 | Inosine-5'-monophosphate dehydrogenase. | Conserved hypothetical protein. | 0.903 |
MYPE3150 | MYPE990 | gene:10731419 | gene:10731191 | Inosine-5'-monophosphate dehydrogenase. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.834 |
MYPE3790 | MYPE1710 | gene:10731494 | gene:10731270 | ATP-dependent protease binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | Thioredoxin; Belongs to the thioredoxin family. | 0.464 |
MYPE3790 | MYPE3150 | gene:10731494 | gene:10731419 | ATP-dependent protease binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | Inosine-5'-monophosphate dehydrogenase. | 0.558 |
MYPE3790 | MYPE6910 | gene:10731494 | gene:10731812 | ATP-dependent protease binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.631 |
MYPE3790 | MYPE8960 | gene:10731494 | gene:10732018 | ATP-dependent protease binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ClpB [...] | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.839 |