STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaEConserved hypothetical protein; MPN014(new), 140(Himmelreich et al., 1996). (212 aa)    
Predicted Functional Partners:
dnaE-2
DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
  
  
0.920
dnaB
Replicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity; Belongs to the helicase family. DnaB subfamily.
  
 
 0.898
D12_orf257
Hypothetical protein; MPN013(new), 141(Himmelreich et al., 1996); Belongs to the UPF0134 family.
 
  
 0.854
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.703
A65_orf118
Hypothetical protein; MPN287(new), 549(Himmelreich et al., 1996); see: MPN013; Belongs to the UPF0134 family.
  
  
 0.663
pheT
phenylalanyl-tRNA synthetase beta chain; MPN106(new), 049(Himmelreich et al., 1996); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.649
A65_orf115
Hypothetical protein; MPN283(new), 553(Himmelreich et al., 1996); see: MPN013; Belongs to the UPF0134 family.
   
  
 0.641
H91_orf216
Hypothetical protein; MPN344(new), 493(Himmelreich et al., 1996); see: MPN013; Belongs to the UPF0134 family.
   
  
 0.641
P02_orf126
Hypothetical protein; MPN504(new), 338(Himmelreich et al., 1996); see: MPN013; Belongs to the UPF0134 family.
   
  
 0.638
GT9_orf148
Conserved hypothetical protein; MPN204(new), 628(Himmelreich et al., 1996); see: MPN013; Belongs to the UPF0134 family.
      
 0.631
Your Current Organism:
Mycoplasma pneumoniae M129
NCBI taxonomy Id: 272634
Other names: M. pneumoniae M129, Mycoplasma pneumoniae ATCC 29342, Mycoplasma pneumoniae str. M129, Mycoplasma pneumoniae strain M129
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