hit1 protein (Mycoplasma pneumoniae M129) - STRING interaction network

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Predicted Interactions

gene neighborhood

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[Homology]

Score

Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996). (144 aa)

Predicted Functional Partners:

A65_orf266

0.773

yaaK

0.670

C09_orf718

0.661

rpoC

0.592

rpoA

0.569

rpoB

0.536

dacB

0.505

spoT

0.486

pheT

0.478

topA

0.469

Your Current Organism:

Mycoplasma pneumoniae M129

NCBI taxonomy Id: 272634
Other names: M. pneumoniae M129, Mycoplasma pneumoniae ATCC 29342, Mycoplasma pneumoniae str. M129, Mycoplasma pneumoniae strain M129

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A65_orf266	hit1	MPN_274	MPN_273	ABC transporter (sulfate/molybdenum) permease subunit; MPN274(new), 562(Himmelreich et al., 1996).	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	0.773
A65_orf266	yaaK	MPN_274	MPN_275	ABC transporter (sulfate/molybdenum) permease subunit; MPN274(new), 562(Himmelreich et al., 1996).	Conserved hypothetical protein; MPN275(new), 561(Himmelreich et al., 1996).	0.577
C09_orf718	hit1	MPN_110	MPN_273	Conserved hypothetical protein; MPN110(new), 045(Himmelreich et al., 1996).	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	0.661
C09_orf718	rpoA	MPN_110	MPN_191	Conserved hypothetical protein; MPN110(new), 045(Himmelreich et al., 1996).	RNA polymerase alpha core subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.997
C09_orf718	rpoB	MPN_110	MPN_516	Conserved hypothetical protein; MPN110(new), 045(Himmelreich et al., 1996).	RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.995
C09_orf718	rpoC	MPN_110	MPN_515	Conserved hypothetical protein; MPN110(new), 045(Himmelreich et al., 1996).	DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.926
dacB	hit1	MPN_244	MPN_273	Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria; Belongs to the adenylate cyclase family. DacB/CdaS subfamily.	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	0.505
dacB	spoT	MPN_244	MPN_397	Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria; Belongs to the adenylate cyclase family. DacB/CdaS subfamily.	p)ppGpp 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity); Belongs to the RelA/SpoT family.	0.414
dacB	topA	MPN_244	MPN_261	Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria; Belongs to the adenylate cyclase family. DacB/CdaS subfamily.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.471
hit1	A65_orf266	MPN_273	MPN_274	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	ABC transporter (sulfate/molybdenum) permease subunit; MPN274(new), 562(Himmelreich et al., 1996).	0.773
hit1	C09_orf718	MPN_273	MPN_110	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	Conserved hypothetical protein; MPN110(new), 045(Himmelreich et al., 1996).	0.661
hit1	dacB	MPN_273	MPN_244	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria; Belongs to the adenylate cyclase family. DacB/CdaS subfamily.	0.505
hit1	pheT	MPN_273	MPN_106	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	phenylalanyl-tRNA synthetase beta chain; MPN106(new), 049(Himmelreich et al., 1996); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.	0.478
hit1	rpoA	MPN_273	MPN_191	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	RNA polymerase alpha core subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.569
hit1	rpoB	MPN_273	MPN_516	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.536
hit1	rpoC	MPN_273	MPN_515	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.592
hit1	spoT	MPN_273	MPN_397	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	p)ppGpp 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity); Belongs to the RelA/SpoT family.	0.486
hit1	topA	MPN_273	MPN_261	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.469
hit1	yaaK	MPN_273	MPN_275	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	Conserved hypothetical protein; MPN275(new), 561(Himmelreich et al., 1996).	0.670
pheT	hit1	MPN_106	MPN_273	phenylalanyl-tRNA synthetase beta chain; MPN106(new), 049(Himmelreich et al., 1996); Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.	Nucleotidyl hydrolases/transferase; MPN273(new), 563(Himmelreich et al., 1996).	0.478