STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A19_orf591Pertussis toxin subunit s1-like protein; Acts as an ADP-ribosylating toxin, which may transfer the ADP-ribosyl group from NAD(+) to specific amino acids in target proteins. Elicits cytopathic effects in mammalian cells, such as disorganization and disruption of respiratory epithelial integrity in tracheal epithelium and vacuolization in the cytoplasm of CHO and HeLa cells; Belongs to the bacterial exotoxin subunit A family. (591 aa)    
Predicted Functional Partners:
P02_orf140
NifU-like; MPN488(new), 353(Himmelreich et al., 1996); complementing transferase subunit for MPN488.
  
 
 0.945
MPN_371
Hypothetical protein; MPN371(new), 466(Himmelreich et al., 1996).
     
 0.744
E07_orf301
Putative lipoprotein; MPN133(new), 022(Himmelreich et al., 1996).
  
  
 0.715
p30
30K adhesin-related protein; Adhesin necessary for successful cytadherence and virulence.
  
  
 0.623
P1
Adhesin P1; The protein is the major adhesin mediating the attachment of this mycoplasma to respiratory epithelium.
   
  
 0.620
MPN_388
Conserved hypothetical protein; MPN388(new).
      
 0.564
cpsG
CpsG; MPN066(new), 088(Himmelreich et al., 1996); similar to phosphomannomutase and phosphoglucomutase; Belongs to the phosphohexose mutase family.
     
 0.542
hmw3
Cytadherence accessory protein HMW3; Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle. Essential for successful surface parasitism.
   
  
 0.536
hmw1
Cytadherence accessory protein HMW1; Component of the cytoskeleton-like structure which stabilizes the shape of the wall-less Mycoplasma. This cytoskeleton-like network of accessory proteins containing HMW proteins 1 to 5 allows the proper anchoring of cytadhesin proteins in the mycoplasmal membrane at the attachment organelle (By similarity).
  
  
 0.528
Orf6
Cytadherence protein; MPN142(new), 013(Himmelreich et al., 1996).
   
  
 0.512
Your Current Organism:
Mycoplasma pneumoniae M129
NCBI taxonomy Id: 272634
Other names: M. pneumoniae M129, Mycoplasma pneumoniae ATCC 29342, Mycoplasma pneumoniae str. M129, Mycoplasma pneumoniae strain M129
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