| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C09_orf910 | udk | MPN_119 | MPN_561 | Hypothetical protein; MPN119(new), 036(Himmelreich et al., 1996); contains j-domain of DnaJ and a domain common to cytadherence proteins. | Uridine kinase; MPN561(new), 281(Himmelreich et al., 1996). | 0.600 |
| C09_orf910 | xdj1 | MPN_119 | MPN_002 | Hypothetical protein; MPN119(new), 036(Himmelreich et al., 1996); contains j-domain of DnaJ and a domain common to cytadherence proteins. | DnaJ-like protein; MPN002(new), 152(Himmelreich et al., 1996). | 0.572 |
| NadD | udk | MPN_336 | MPN_561 | Hypothetical protein; MPN336(new), 501(Himmelreich et al., 1996); bidomain: nucleotidyl transferase and conserved hypothetical second domain, probably phosphopantetheine adenylyltransferase activity. | Uridine kinase; MPN561(new), 281(Himmelreich et al., 1996). | 0.627 |
| cdd | udk | MPN_065 | MPN_561 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Uridine kinase; MPN561(new), 281(Himmelreich et al., 1996). | 0.917 |
| cdd | upp | MPN_065 | MPN_033 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.473 |
| dnaJ | secY | MPN_021 | MPN_184 | Heat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.721 |
| dnaJ | udk | MPN_021 | MPN_561 | Heat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | Uridine kinase; MPN561(new), 281(Himmelreich et al., 1996). | 0.625 |
| dnaJ | yb95 | MPN_021 | MPN_020 | Heat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | Helicase-like protein; MPN020(new), 134(Himmelreich et al., 1996); Belongs to the SNF2/RAD54 helicase family. | 0.687 |
| gap | pyrH | MPN_430 | MPN_632 | Glycerladehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.415 |
| gap | udk | MPN_430 | MPN_561 | Glycerladehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] | Uridine kinase; MPN561(new), 281(Himmelreich et al., 1996). | 0.965 |
| pyrH | gap | MPN_632 | MPN_430 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | Glycerladehyde-3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate dehydrogenase [...] | 0.415 |
| pyrH | secY | MPN_632 | MPN_184 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.421 |
| pyrH | udk | MPN_632 | MPN_561 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | Uridine kinase; MPN561(new), 281(Himmelreich et al., 1996). | 0.939 |
| pyrH | upp | MPN_632 | MPN_033 | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.980 |
| secY | dnaJ | MPN_184 | MPN_021 | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | Heat shock protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.721 |
| secY | pyrH | MPN_184 | MPN_632 | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.421 |
| secY | udk | MPN_184 | MPN_561 | Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | Uridine kinase; MPN561(new), 281(Himmelreich et al., 1996). | 0.709 |
| udk | C09_orf910 | MPN_561 | MPN_119 | Uridine kinase; MPN561(new), 281(Himmelreich et al., 1996). | Hypothetical protein; MPN119(new), 036(Himmelreich et al., 1996); contains j-domain of DnaJ and a domain common to cytadherence proteins. | 0.600 |
| udk | NadD | MPN_561 | MPN_336 | Uridine kinase; MPN561(new), 281(Himmelreich et al., 1996). | Hypothetical protein; MPN336(new), 501(Himmelreich et al., 1996); bidomain: nucleotidyl transferase and conserved hypothetical second domain, probably phosphopantetheine adenylyltransferase activity. | 0.627 |
| udk | cdd | MPN_561 | MPN_065 | Uridine kinase; MPN561(new), 281(Himmelreich et al., 1996). | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | 0.917 |
STRING v12.5 is now available!
