STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MYPU_2580FOLD BIFUNCTIONAL PROTEIN [INCLUDES: METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (272 aa)    
Predicted Functional Partners:
MYPU_3390
SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.978
MYPU_0450
METHIONYL-TRNA FORMYLTRANSFERASE; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.968
MYPU_5380
THYMIDYLATE SYNTHASE (TS) (TSASE); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.933
MYPU_2570
VALYL-TRNA SYNTHETASE (VALINE--TRNA LIGASE) (VALRS); Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
  
    0.862
MYPU_6710
Conserved hypothetical protein; Identified by sequence similarity; possible; similar to SWISS-PROT:P47488 (Y246_MYCGE) Blastp2 P=2e-52 C=58%.
      0.751
MYPU_4880
XAA-PRO AMINOPEPTIDASE; Identified by sequence similarity; possible; similar to SWISS-PROT:P54518 (YQHT_BACSU) Blastp2 P=2e-64 C=58% Pfscan: pos. 121-348 PF00557 | PEP_M24 metallopeptidase family M24 (PDOC00417) (PDOC00575) pos. 282-294 PS00491 | PROLINE_PEPTIDASE Aminopeptidase P and proline dipeptidase signature.
    
 0.719
MYPU_7610
DIHYDROLIPOAMIDE DEHYDROGENASE (E3 COMPONENT OF PYRUVATE COMPLEX); Identified by sequence similarity; possible; similar to SWISS-PROT:P47513 (DLDH_MYCGE) Blastp2 P=0 C=45%.
     
 0.617
MYPU_2590
TRANSLATION INITIATION FACTOR IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
     
 0.616
MYPU_2600
50S RIBOSOMAL PROTEIN L35; Identified by sequence similarity; probable; similar to SWISS-PROT:Q05428 (RL35_MYCFE) Blastp2 P=9e-14 C=63%; Belongs to the bacterial ribosomal protein bL35 family.
       0.614
MYPU_7200
DNA POLYMERASE I (POL I); 5'-3' exonuclease acting preferentially on double-stranded DNA.
  
  
 0.599
Your Current Organism:
Mycoplasma pulmonis
NCBI taxonomy Id: 272635
Other names: M. pulmonis UAB CTIP, Mycoplasma pulmonis UAB CTIP, Mycoplasma pulmonis str. UAB CTIP, Mycoplasma pulmonis strain UAB CTIP
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