STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MYPU_5370DIHYDROFOLATE REDUCTASE; Identified by sequence similarity; probable; similar to SWISS-PROT:P47470 (DYR_MYCGE) Blastp2 P=6e-39 C=64%; Belongs to the dihydrofolate reductase family. (179 aa)    
Predicted Functional Partners:
MYPU_5380
THYMIDYLATE SYNTHASE (TS) (TSASE); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.997
MYPU_3390
SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.939
MYPU_0450
METHIONYL-TRNA FORMYLTRANSFERASE; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.936
MYPU_2780
DEOXYCYTIDYLATE DEAMINASE (DCMP DEAMINASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P32321 (DCTD_HUMAN) Blastp2 P=5e-38 C=66%.
 
  
 0.830
MYPU_7780
PEPTIDE METHIONINE SULFOXIDE REDUCTASE (PEPTIDE MET(O) REDUCTASE); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
  
  
 0.712
MYPU_5390
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE BETA CHAIN (RIBONUCLEOTIDE REDUCTASE); Identified by sequence similarity; probable; similar to SWISS-PROT:P75461 (RIR2_MYCPN) Blastp2 P=0 C=77%.
  
  
 0.593
MYPU_5410
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (RIBONUCLEOTIDE REDUCTASE); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
  
 0.554
MYPU_5360
Conserved hypothetical protein; Identified by sequence similarity; putative; similar to SWISS-PROT:P37545 (YABD_BACSU) Blastp2 P=1e-37 C=33% Pfscan: pos. 191-434 PF01026 | UPF0006 Uncharacterized protein family (PDOC00836) pos. 305-315 PS01090 | UPF0006_2 Uncharacterized protein family UPF0006 signature 2.
  
    0.552
MYPU_5400
RIBONUCLEOPROTEIN NRDI; Probably involved in ribonucleotide reductase function.
  
    0.552
MYPU_1140
1-acyl-sn-glycerol-3-phosphate acyltransferase; Identified by sequence similarity; possible; similar to SWISS-PROT:P75479 (PLSC_MYCPN) Blastp2 P=2e-24 C=48%.
  
  
 0.447
Your Current Organism:
Mycoplasma pulmonis
NCBI taxonomy Id: 272635
Other names: M. pulmonis UAB CTIP, Mycoplasma pulmonis UAB CTIP, Mycoplasma pulmonis str. UAB CTIP, Mycoplasma pulmonis strain UAB CTIP
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