STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MYPU_7020S-ADENOSYLMETHIONINE SYNTHETASE (METHIONINE ADENOSYLTRANSFERASE) (ADOMET SYNTHETASE); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (376 aa)    
Predicted Functional Partners:
MYPU_1860
CPG DNA METHYLASE (CYTOSINE-SPECIFIC METHYLTRANSFERASE SSSI); Identified by sequence similarity; possible; similar to SWISS-PROT:P15840 (MTSI_SPISQ) Blastp2 P=4e-22 C=44%; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.939
MYPU_0430
CPG DNA METHYLASE (CYTOSINE-SPECIFIC METHYLTRANSFERASE); Identified by sequence similarity; possible; similar to SWISS-PROT:P15840 (MTSI_SPISQ) Blastp2 P=5e-46 C=51%; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
    
 0.918
MYPU_7780
PEPTIDE METHIONINE SULFOXIDE REDUCTASE (PEPTIDE MET(O) REDUCTASE); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
   
 
 0.757
MYPU_7330
HEAT SHOCK PROTEIN DNAJ (activation of DNAK); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent intera [...]
   
 
 0.732
MYPU_6660
CTP SYNTHASE (UTP--AMMONIA LIGASE) (CTP SYNTHETASE); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
 
 0.722
MYPU_3390
SERINE HYDROXYMETHYLTRANSFERASE (SERINE METHYLASE) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.703
MYPU_4900
METHIONYL-TRNA SYNTHETASE (METHIONINE--TRNA LIGASE) (METRS); Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.
  
  
 0.675
MYPU_3470
PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (PHENYLALANINE--TRNA LIGASE BETA CHAIN) (PHERS); Identified by sequence similarity; possible; similar to SWISS-PROT:P75563 (SYFB_MYCPN) Blastp2 P=3e-43 C=46%; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
  
  
 0.642
MYPU_6820
GLUTAMYL-TRNA SYNTHETASE (GLUTAMATE--TRNA LIGASE) (GLURS); Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
  
  
 0.632
MYPU_4240
SPERMIDINE/PUTRESCINE ABC TRANSPORTER PERMEASE PROTEIN POTB; Identified by sequence similarity; putative; similar to SWISS-PROT:P75058 (POTB_MYCPN) Blastp2 P=7e-25 C=37% Pfscan: pos. 150-209 GC0426 | BPD_TRANSP_INN_MEMBR Binding-protein-dependent transport systems inne pos. 115-124 PS00599 | AA_TRANSFER_CLASS_2 Aminotransferases class-II pyridoxal-phosphate attachment site pos. 161-189 PS00402 | BPD_TRANSP_INN_MEMBR Binding-protein-dependent transport systems inner membrane comp. sign.
     
 0.619
Your Current Organism:
Mycoplasma pulmonis
NCBI taxonomy Id: 272635
Other names: M. pulmonis UAB CTIP, Mycoplasma pulmonis UAB CTIP, Mycoplasma pulmonis str. UAB CTIP, Mycoplasma pulmonis strain UAB CTIP
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