STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MYPU_7820EXODEOXYRIBONUCLEASE V ALPHA CHAIN; Identified by sequence similarity; unknown; similar to SWISS-PROT:P04993 (EX5A_ECOLI) Blastp2 P=9e-12 C=11%. (694 aa)    
Predicted Functional Partners:
MYPU_0020
DNA POLYMERASE III, BETA CHAIN; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
  
 
 0.922
MYPU_4710
DNA TOPOISOMERASE I (OMEGA-PROTEIN) (RELAXING ENZYME) (UNTWISTING ENZYME) (SWIVELASE); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then un [...]
   
 
 0.809
MYPU_7810
PEPTIDYL-TRNA HYDROLASE (PTH); The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family.
  
    0.797
MYPU_7800
Conserved hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
       0.788
MYPU_2520
RECOMBINATION PROTEIN RECA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
   
 
 0.776
MYPU_5500
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
 
  0.760
MYPU_7680
ATP-DEPENDENT HELICASE PCRA; Identified by sequence similarity; possible; similar to SWISS-PROT:Q53727 (PCRA_STAAU) Blastp2 P=0 C=51%.
  
 
 0.733
MYPU_7780
PEPTIDE METHIONINE SULFOXIDE REDUCTASE (PEPTIDE MET(O) REDUCTASE); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
     
 0.733
MYPU_4250
SPERMIDINE/PUTRESCINE ABC TRANSPORTER ATP-BINDING PROTEIN POTA; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.
  
 
 0.720
MYPU_6980
ATP-DEPENDENT HELICASE PCRA; Identified by sequence similarity; possible; similar to SWISS-PROT:Q53727 (PCRA_STAAU) Blastp2 P=0 C=52%.
  
 
 0.699
Your Current Organism:
Mycoplasma pulmonis
NCBI taxonomy Id: 272635
Other names: M. pulmonis UAB CTIP, Mycoplasma pulmonis UAB CTIP, Mycoplasma pulmonis str. UAB CTIP, Mycoplasma pulmonis strain UAB CTIP
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