node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aroC | hisC | PM0359 | PM1199 | AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | HisH; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.587 |
aroC | hisD | PM0359 | PM1198 | AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.741 |
aroC | hisH_1 | PM0359 | PM0838 | AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | HisH; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.634 |
hisA | hisB | PM1203 | PM1200 | HisA. | HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.997 |
hisA | hisC | PM1203 | PM1199 | HisA. | HisH; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.962 |
hisA | hisD | PM1203 | PM1198 | HisA. | HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.989 |
hisA | hisF | PM1203 | PM1204 | HisA. | HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisA | hisG | PM1203 | PM1195 | HisA. | HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.983 |
hisA | hisH_1 | PM1203 | PM0838 | HisA. | HisH; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.813 |
hisA | hisH_2 | PM1203 | PM1202 | HisA. | HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.998 |
hisA | hisIE | PM1203 | PM1206 | HisA. | HisIE; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA | vatB | PM1203 | PM1197 | HisA. | VatB. | 0.508 |
hisB | hisA | PM1200 | PM1203 | HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | HisA. | 0.997 |
hisB | hisC | PM1200 | PM1199 | HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | HisH; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | PM1200 | PM1198 | HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | HisD; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | PM1200 | PM1204 | HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). | 0.999 |
hisB | hisG | PM1200 | PM1195 | HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.996 |
hisB | hisH_1 | PM1200 | PM0838 | HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | HisH; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.998 |
hisB | hisH_2 | PM1200 | PM1202 | HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). | 0.999 |
hisB | hisIE | PM1200 | PM1206 | HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | HisIE; In the C-terminal section; belongs to the PRA-PH family. | 0.999 |