Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
scrkscrK fructokinase (EC 2.7.1.4); Belongs to the carbohydrate kinase PfkB family. (305 aa)    
Predicted Functional Partners:
PAB1348
glmS-like glutamine-fructose-6-phosphate transaminase related protein.
 
 
 0.936
fbp-2
Fbp fructose 1,6-bisphosphatase (EC 3.1.3.11); Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
     
 0.913
glmS
glmS Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
    
 0.912
manC
manC mannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase, bifunctional enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.
    
 0.910
pgiA
Glucose-6-phosphate isomerase.
  
 
 0.907
PAB1622
Hypothetical protein.
 
   
 0.650
PAB0689
Hypothetical protein.
 
   
 0.630
PABs11404
Conserved hypothetical protein (N-terminal part).
       0.578
purA
purA adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.550
PAB1900
Conserved hypothetical protein (C-terminal part).
       0.548
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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