Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
PAB0673Hypothetical protein. (129 aa)    
Predicted Functional Partners:
PAB0672
Hypothetical protein.
       0.776
rtcB
rtcB homolog, intein containing; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family.
       0.717
nB
panB 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11); Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
       0.717
PAB1946
Hypothetical protein; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently (By similarity). Chaperone or modulator of proteins involved in DNA or RNA processing. Protects the tRNA (cytosine-5-)- methyltransferase PAB1947 against aggregation and increases its specificity; Belongs to the archease family.
       0.717
PAB1947
Sun/NOL1/NOP2 nucleolar protein; Catalyzes AdoMet-dependent formation of m5C in tRNA. In the presence of protein archease, specifically methylates the cytosine at position 49 (m5C49) of tRNA. In the absence of archease, catalyzes the formation of m5C at many locations in tRNAs or rRNAs.
       0.717
PAB1981
Glycosyltransferase.
       0.710
truA
truA pseudouridylate synthase I; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family.
       0.585
PAB0674
Cytochrome C biogenesis protein.
       0.557
PAB0675
fwdE-like tungsten formylmethanofuran dehydrogenase, subunit E homolog.
       0.410
hemv-3
hemV-3 iron (III) ABC transporter, ATP-binding protein.
       0.410
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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