Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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rnzPutative sulfatase, ATSA/ELAC family; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (307 aa)    
Predicted Functional Partners:
traB
Signaling protein.
       0.933
rnj
Metallo-beta-lactamase superfamily protein; A highly processive 5'-3' exoribonuclease; no evidence has been seen for endonuclease activity. Prefers 5'-phosphate or 5'- hydroxyl ends; 5'-triphosphate substrates are very poorly degraded, does not degrade circular RNA. Does not degrade pre-tRNA(Trp) suggesting it is inhibited by strong secondary structures. Also degrades ssNDA but not dsDNA.
      
 0.892
endA
Archaeal tRNA intron endonuclease (EC 3.1.27.9); Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
 
  
 0.812
PAB2420
Arylmalonate decarboxylase or maleate isomerase (EC 5.2.1.1).
       0.787
rtcB
rtcB homolog, intein containing; GTP-dependent RNA ligase that is involved in tRNA splicing and RNA repair. Joins RNA with 2',3'-cyclic-phosphate or 3'-phosphate ends to RNA with 5'-hydroxy ends; Belongs to the RtcB family.
 
   
 0.784
mvk
Mvk mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
  
   
 0.782
rph
Rph ribonuclease PH, exosome complex exonuclease; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails (Probable).
  
  
 0.778
trpA
trpA tryptophan synthase, subunit alpha (EC 4.2.1.20); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate; Belongs to the TrpA family.
     
 0.772
fau-1
Ribonuclease E homolog, putative; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences.
  
  
 0.750
cysS
cysS cysteinyl-tRNA synthetase.
  
  
 0.747
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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