close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAB0759Predicted ATPases of PP-loop superfamily. (226 aa)    
Predicted Functional Partners:
dphB
Dph5 diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
 
 
 0.963
ppa
Ppa thermostable inorganic pyrophosphatase (EC 3.6.1.1) (pyrophosphate phospho-hydrolase) (PPASE); Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
      
 0.877
guaA-C
guaA-C GMP synthase [glutamine-hydrolyzing] pyrophosphatase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP.
     
 0.781
PAB0761
Transport protein permease component, substrate unknown.
  
    0.778
PAB0760
RNA methyltransferase, putative; Catalyzes the formation of 5-methyl-uridine at position equivalent to 747 (m5U747) in 23S rRNA (m5U859 in the P.abyssi numbering).
       0.776
fus
Fus translation elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTP [...]
  
 
 0.769
asnB
Asparagine synthase (glutamine-hydrolyzing) (EC 6.3.5.4).
      0.763
PAB0762
preP prolyl oligopeptidase (EC 3.4.21.26).
       0.693
PAB0825
Translation initiation inhibitor; Belongs to the RutC family.
      
 0.582
PAB0746
Putative diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.
  
   
 0.447
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.