Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
napA-4napA-4 Na+/H+ antiporter. (390 aa)    
Predicted Functional Partners:
PAB7309
Transmembrane protein, putative.
       0.933
mfnA
Glutamate decarboxylase (EC 4.1.1.15); Catalyzes the decarboxylation of L-aspartate to produce beta- alanine; Belongs to the group II decarboxylase family. MfnA subfamily.
  
  
 0.877
PAB1576
Haloacid dehalogenase-like hydrolase.
       0.801
PAB1577
Integral membrane protein, putative.
       0.801
PAB0810
Predicted ATPase.
  
    0.721
rad50
Rad50 purine ntpase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily.
  
    0.721
rad32
Rad32/mre11 DNA repair protein (EC 3.1.-.-); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
       0.712
ppa
Ppa thermostable inorganic pyrophosphatase (EC 3.6.1.1) (pyrophosphate phospho-hydrolase) (PPASE); Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
     
 0.658
PAB0813
Putative 5' to 3'nuclease, nura homolog.
       0.654
amyA
amyA alpha-amylase (or 4-alpha-glucanotransferase).
     
 0.609
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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