| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PAB0810 | PAB0813 | PAB0810 | PAB0813 | Predicted ATPase. | Putative 5' to 3'nuclease, nura homolog. | 0.935 |
| PAB0810 | rad32 | PAB0810 | PAB0811 | Predicted ATPase. | Rad32/mre11 DNA repair protein (EC 3.1.-.-); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.910 |
| PAB0810 | rad50 | PAB0810 | PAB0812 | Predicted ATPase. | Rad50 purine ntpase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.928 |
| PAB0813 | PAB0810 | PAB0813 | PAB0810 | Putative 5' to 3'nuclease, nura homolog. | Predicted ATPase. | 0.935 |
| PAB0813 | rad32 | PAB0813 | PAB0811 | Putative 5' to 3'nuclease, nura homolog. | Rad32/mre11 DNA repair protein (EC 3.1.-.-); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.818 |
| PAB0813 | rad50 | PAB0813 | PAB0812 | Putative 5' to 3'nuclease, nura homolog. | Rad50 purine ntpase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.837 |
| PAB2163 | PAB2385 | PAB2163 | PAB2385 | RPA41 subunit of the hetero-oligomeric complex involved in homologous recombination. | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | 0.812 |
| PAB2163 | fen | PAB2163 | PAB1877 | RPA41 subunit of the hetero-oligomeric complex involved in homologous recombination. | Fen1 FLAP endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathw [...] | 0.711 |
| PAB2163 | lig | PAB2163 | PAB2002 | RPA41 subunit of the hetero-oligomeric complex involved in homologous recombination. | Lig DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.524 |
| PAB2163 | rad32 | PAB2163 | PAB0811 | RPA41 subunit of the hetero-oligomeric complex involved in homologous recombination. | Rad32/mre11 DNA repair protein (EC 3.1.-.-); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.879 |
| PAB2163 | rad50 | PAB2163 | PAB0812 | RPA41 subunit of the hetero-oligomeric complex involved in homologous recombination. | Rad50 purine ntpase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.797 |
| PAB2163 | topA | PAB2163 | PAB1430 | RPA41 subunit of the hetero-oligomeric complex involved in homologous recombination. | topA DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA [...] | 0.905 |
| PAB2385 | PAB2163 | PAB2385 | PAB2163 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | RPA41 subunit of the hetero-oligomeric complex involved in homologous recombination. | 0.812 |
| PAB2385 | fen | PAB2385 | PAB1877 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | Fen1 FLAP endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathw [...] | 0.922 |
| PAB2385 | lig | PAB2385 | PAB2002 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | Lig DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. | 0.774 |
| PAB2385 | rad32 | PAB2385 | PAB0811 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | Rad32/mre11 DNA repair protein (EC 3.1.-.-); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.866 |
| PAB2385 | rad50 | PAB2385 | PAB0812 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | Rad50 purine ntpase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.696 |
| PAB2385 | topA | PAB2385 | PAB1430 | ERCC2/XPD/rad3 DNA repair helicase, TFIIH helicase beta subunit homolog. | topA DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA [...] | 0.764 |
| atpD | rad32 | PAB2379 | PAB0811 | atpD archaeal/vacuolar-type H+-transporting ATP synthase, subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. | Rad32/mre11 DNA repair protein (EC 3.1.-.-); Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.776 |
| atpD | rad50 | PAB2379 | PAB0812 | atpD archaeal/vacuolar-type H+-transporting ATP synthase, subunit D; Produces ATP from ADP in the presence of a proton gradient across the membrane. | Rad50 purine ntpase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.538 |
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