Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
enoEno enolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase) (EC 4.2.1.11); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa)    
Predicted Functional Partners:
PAB1441
Pyk pyruvate kinase (EC 2.7.1.40) (PK); Belongs to the pyruvate kinase family.
 
 0.998
pgk
Pgk 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
 
 
 0.991
gap
Gap glyceraldehyde 3-phosphate dehydrogenase.
  
 
 0.989
tpiA
tpiA triosephosphate isomerase, archaeal triose phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
 
 0.989
apgM
Probable phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
    
 0.979
ppsA
ppsA probable phosphoenolpyruvate synthase (pyruvate,water dikinase) (PEP synthase) (EC 2.7.9.2); Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
 
  
 0.976
PAB1021
Putative hydroxypyruvate reductase.
    
 0.965
pckG
pckA phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
     
 0.950
fbp-2
Fbp fructose 1,6-bisphosphatase (EC 3.1.3.11); Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).
    
 0.946
eno-like
Eno-like enolase related.
  
  
 
0.922
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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