STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purApurA adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (339 aa)    
Predicted Functional Partners:
purB
purB adenylosuccinate lyase (EC 4.3.2.2).
 
 0.999
guaB
guaB inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) (IMP dehydrogenase) (IMPDH) (IMPD); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.997
aspB-2
aspC-2 aspartate aminotransferase (EC 2.6.1.1).
  
 0.973
purL
purL phosphoribosylformylglycinamidine synthase II (EC 6.3.5.3); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is [...]
  
  
 0.957
pyrB
pyrB aspartate carbamoyltransferase, catalytic subunit.
  
 
 0.957
asnB
Asparagine synthase (glutamine-hydrolyzing) (EC 6.3.5.4).
  
 
 0.941
asnA-2
asnA-2 L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase) (asparaginase 2).
    
  0.936
nadB
nadB L-aspartate oxidase (EC 1.4.3.16) (quinolinate synthetase B); Catalyzes the oxidation of L-aspartate to iminoaspartate.
  
  
 0.931
guaA-N
guaA-N GMP synthase-glutamine amidotransferase subunit (EC 6.3.5.2); Catalyzes the synthesis of GMP from XMP.
 
  
 0.924
PAB1605
Putative putative asparagine synthetase (glutamine-hydrolyzing) (EC 6.3.5.4).
  
 
 0.923
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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