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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAB1968ADP-ribose pyrophosphatase (nudix family) (EC 3.6.1.13). (173 aa)    
Predicted Functional Partners:
PAB1318
nadM nicotinamide nucleotide adenylyltransferase.
   
 0.886
PAB1967
Carbohydrate kinase, PfkB family.
     
 0.809
imp1
Imp1 hypothetical myo-inositol monophosphosphatase.
 
  
 0.707
apbA
panE 2-dehydropantoate reductase (EC 1.1.1.169); Catalyzes the NAD(P)H-dependent reduction of ketopantoate into pantoic acid.
      0.569
nth
Nth endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
     
 0.520
nadC-like
Quinolinate phosphoribosyl transferase, putative.
     
 0.510
PAB0401
Hypothetical protein.
       0.498
manC
manC mannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase, bifunctional enzyme; Belongs to the mannose-6-phosphate isomerase type 2 family.
  
  
 0.458
nadE
nadE NH(3)-dependent NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
  
  
 0.457
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication (By similarity). Regulates activity of NucS endonuclease and prevents non- specific cleavage.
     
 0.448
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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