Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PAB2147ABC-type transport system, ATPase component, substrate unknown. (579 aa)    
Predicted Functional Partners:
PAB2148
ABC-type transport system, ATPase component, substrate unknown.
 
    
0.916
PAB1789
ATPase of the AAA+ family.
 
 
 0.608
PAB0764
Histone deacetylase.
  
 0.596
pan
26S protease regulatory subunit 4; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-2 [...]
  
  0.595
infB
infB intein containing translation initiation factor aIF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 (By similarity).
 
 
 
 0.562
sucC-like
acdB acetate--coA ligase (ADP-forming) (EC 6.2.1.13), beta chain.
       0.515
rpl40E
rpl40E LSU ribosomal protein L40E; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 
  0.515
fabG
Short-chain alcohol dehydrogenase, putative glucose-1-dehydrogenase.
 
 
 0.477
glpk
glpK glycerol kinase (EC 2.7.1.30); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate.
  
 0.475
pgk
Pgk 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
 
 
 0.470
Your Current Organism:
Pyrococcus abyssi
NCBI taxonomy Id: 272844
Other names: P. abyssi GE5, Pyrococcus abyssi GE5, Pyrococcus abyssi str. GE5, Pyrococcus abyssi str. Orsay, Pyrococcus abyssi strain GE5
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